An in vitro study of the permeabilities of frozen and reconstituted cattle skin and human skin to levamisole was done. Cattle skin was 400 times more permeable to levamisole from an organic solvent (largely 2-ethoxyethanol) than was human skin. The diffusion coefficient value of levamisole in cattle skin and the partition coefficient value of levamisole from the organic solvent into the skin suggested that a relatively large amount of drug passed through skin appendages such as hair follicles or sweat/sebaceous ducts. Transcellular transport across the stratum corneum was rate-determining in human skin penetration.
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| http://dx.doi.org/10.1002/jps.2600710413 | DOI Listing |
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