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Inhibition of acyl-CoA synthetase long-chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction.
Mol Oncol
January 2025
Center for Molecular Medicine, MaineHealth Institute for Research, Scarborough, ME, USA.
Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5-year survival rate of 59%. Dysregulation of fatty acid (FA) metabolism is associated with MM development and progression; however, the underlying mechanisms remain unclear. Herein, we explore the roles of long-chain fatty acid coenzyme A ligase (ACSL) family members in MM.
View Article and Find Full Text PDFExploring the Molecular Composition of Dissolved Organic Matter and Its Connection to Microbial Communities in Industrial-Scale Anaerobic Digestion of Chicken Manure.
Toxics
January 2025
School of Computer Science and Hubei Key Laboratory of Intelligent Geo-Information Processing, China University of Geosciences, Wuhan 430078, China.
Anaerobic digestion (AD) technology offers significant advantages in addressing environmental issues arising from the intensification of livestock production since it enables waste reduction and energy recovery. However, the molecular composition of dissolved organic matter (DOM) and its linkages to microbial biodiversity during the industrial-scale AD process of chicken manure (CM) remains unclear. In this study, the chemical structure of CM digestate-derived DOM was characterized by using multi-spectroscopic techniques and ultrahigh-resolution mass spectrometry, and the microbial composition was detected by using 16S rRNA gene sequencing.
View Article and Find Full Text PDFPilot-Scale Enzymatic Conversion of Low Stability, High Free Fatty, Squid Oil to an Oxidatively Stable Astaxanthin-Rich Acylglyceride Oil Suitable for Nutritional Applications.
Mar Drugs
January 2025
ARC Industrial Transformation Training Centre for Green Chemistry in Manufacturing, Deakin University, Waurn Ponds, Geelong, VIC 3216, Australia.
Squid viscera, a byproduct of squid processing, contains oil rich in omega-3 fatty acids (up to 10% by mass) and the antioxidant astaxanthin. However, its high free fatty acid (FFA) content compromises stability. To address this, pilot-scale (200 L) enzymatic re-esterification of squid oil using immobilized lipase (Lipozyme RMIM) was demonstrated, resulting in high acylglyceride yields.
View Article and Find Full Text PDFUnderlying Mechanisms of Chromatographic H/D, H/F, and Isomerism Effects in GC-MS.
Metabolites
January 2025
Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, 30623 Hannover, Germany.
Charge-free gaseous molecules labeled with deuterium H (D) atoms elute earlier than their protium-analogs H (H) from most stationary GC phases. This effect is known as the chromatographic H/D isotope effect (IE) and can be calculated by dividing the retention times () of the protiated ( ) to those of the deuterated () analytes: IE = /. Analytes labeled with C, N or O have almost identical retention times and lack a chromatographic isotope effect.
View Article and Find Full Text PDFSeparation of Short-Chain Fatty Acids from Primary Sludge into a Particle-Free Permeate by Coupling Chamber Filter-Press and Cross-Flow Microfiltration: Optimization, Semi-Continuous Operation, and Evaluation.
Membranes (Basel)
January 2025
DVGW-Research Center at the Engler-Bunte-Institute, Water Chemistry and Water Technology, Karlsruhe Institute of Technology, Engler-Bunte-Ring 9, 76131 Karlsruhe, Germany.
Short-chain fatty acids (SCFAs) are valuable metabolic intermediates that are produced during dark fermentation of sludge, which, when capitalized on, can be used as chemical precursors for biotechnological applications. However, high concentrations of solids with SCFAs in hydrolyzed sludge can be highly detrimental to downstream recovery processes. This pilot-scale study addresses this limitation and explores the recovery of SCFAs from primary sludge into a particle-free permeate through a combination of chamber filter-press (material: polyester; mesh size: 100 µm) and cross-flow microfiltration (material: α-AlO; pore size: 0.
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