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Bovine thrombin and streptokinase-activated human plasmin have been labeled with Tc-99m using stannous reduction of pertechnetate under physiological conditions (pH 7.4). The binding efficiency of radiotechnetium to these enzymes is greater than 94%, with less than 5% of reduced but unbound Tc-99m (Sn) complex as assayed by ascending paper radiochromatography using ITLC silica gel plate.
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View Article and Find Full Text PDFObjective and instrumental appraisal of the therapeutic effect of a new inflammatory molecule (pyrasanone) via radio-isotope and clinical assessment is reported. A highly significant decrease in articular uptake of radiotechnetium was observed when pyrasanone was administered for a short period to 6 subjects with classic or definite rheumatoid arthritis. Clinical assessment after prolonged aministration in 40 patients with various rheumatic diseases with pathogenetice inflammation showed a marked anc clinically important anti-inflammatory (and hence analgesic) effct; tolerance was good and there were no side-effects.
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