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Complement C3 of tumor-derived extracellular vesicles promotes metastasis of RCC via recruitment of immunosuppressive myeloid cells.
Proc Natl Acad Sci U S A
January 2025
Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Southeast University, Nanjing 210096, China.
Heterogeneous roles of complement C3 have been implicated in tumor metastasis and are highly context dependent. However, the underlying mechanisms linking C3 to tumor metastasis remain elusive in renal cell carcinoma (RCC). Here, we demonstrate that C3 of RCC cell-derived extracellular vesicles (EVs) contributes to metastasis via polarizing tumor-associated macrophages (TAMs) into the immunosuppressive phenotype and recruiting polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs).
View Article and Find Full Text PDFEnniatin B alters bovine polymorphonuclear leukocytes phagocytosis and extracellular reactive oxygen species production in vitro.
Res Vet Sci
January 2025
Department of Veterinary Medicine and Animal Sciences (DIVAS), University of Milan, Via dell'Università 6, 2600 Lodi, Italy.
Enniatins (ENNs) affect human and animal health. Different ENN analogs have been identified, but Enniatin B (ENN B) is the most detected in foods and feeds. This study investigated the effect of ENN B on bovine polymorphonuclear leukocytes (PMNs) challenged with increasing ENN B concentrations (0.
View Article and Find Full Text PDFThe accumulation of myeloid-derived suppressor cells participates in abdominal infection-induced tumor progression through the PD-L1/PD-1 axis.
Mol Oncol
January 2025
Department of Gastrointestinal Cancer Translational Research, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, with gastrectomy being the primary treatment option. Sepsis, a systemic inflammatory response to infection, may influence tumor growth by creating an immunosuppressive environment conducive to cancer cell proliferation and metastasis. Here, the effect of abdominal infection on tumor growth and metastasis was investigated through the implementation of a peritoneal metastasis model and a subcutaneous tumor model.
View Article and Find Full Text PDFCharacterizing the diabetes-induced pathological changes of the mouse lung by single-cell RNA sequencing.
Life Sci
January 2025
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shiquan 1(st) Rd., Sanmin Dist., Kaohsiung City 807378, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100, Shiquan 1(st) Rd., Sanmin Dist., Kaohsiung 807378, Taiwan; National Pingtung University of Science and Technology, Department of Biological Science and Technology, No. 1, Shuefu Road, Neipu, Pingtung 912301, Taiwan. Electronic address:
Pulmonary disorders are exacerbated by high blood sugar, leading to a disordered immune defense and increased susceptibility to infection. Type 2 diabetes mellitus (T2D) is characterized by insulin resistance and inadequate insulin production. Mechanisms leading to pulmonary alternation due to T2D are not clear.
View Article and Find Full Text PDFSituating the salience and parietal memory networks in the context of multiple parallel distributed networks using precision functional mapping.
Cell Rep
January 2025
Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Psychology, Northwestern University, Evanston, IL 60208, USA. Electronic address:
Brain networks serving higher cognitive functions are widely distributed across frontal and posterior association zones. Two exceptions have been the parietal memory network (PMN) and salience network (SAL), which are typically restricted to posterior (e.g.
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