AI Article Synopsis
- The study explored methods to label o-iodo-hippuric acid (hippuran) with 123I to create an easy one-step preparation kit.
- A catalyst, CuSO4 . 5H2O, was identified as effective, and various parameters like pH and reaction time were optimized.
- The resulting kit is stable for up to 3 months in liquid and 9 months when freeze-dried, demonstrating consistent clinical success in thousands of patients.
Article Abstract
The labelling of o-iodo-hippuric acid (hippuran) with 123I by several methods was investigated with a view to producing a simple one-step kit preparation. The requirements for the final product are high labelling efficiency and high radiochemical purity. A method which incorporates CuSO4 . 5H2O as a catalyst was found which gave promising preliminary results. Such variables as pH, mass of CuSO4 . 5H2O, volume of 0.02 N NaOH containing the 123I, reaction temperature and time were investigated in detail and optimum values obtained. The results have led to the production of a kit which can be stored for up to 3 months in liquid form and up to 9 months if freeze-dried. The kit has been used in several thousand patients and has yielded consistently good clinical results.
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| http://dx.doi.org/10.1007/BF00251643 | DOI Listing |
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