A study was made of antitumor and toxic properties of retinoid C15 which has some characteristic structural features of retinoic acid natural metabolites; such as ethyl-2E, 4E-3-methyl-5-/2,6-dimethyl-6-ethoxycarbonyl-/3-oxo-1-cyclohexene-1-yl/-2,4-pentadienoate. The substance inhibited the growth of transplantable tumors of the uterine cervix. Lewis carcinoma and rumen cancer. This ability was dependent on the tumor growth rate. The substance proved less toxic then retinoic acid or methyl retionate. Injection of retinoid C15 was accompanied by the widening of the paracortical zone of the mesenterial lymph node and by the increased number of lymphoid follicles in the spleen.
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Int J Nanomedicine
January 2025
Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, People's Republic of China.
Purpose: None of the antibody-drug conjugates (ADCs) targeting Claudin 18.2 (CLDN18.2) have received approval from regulatory authorities due to their limited clinical benefits.
View Article and Find Full Text PDFSmall
January 2025
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510000, China.
Degradable and cost-effective cellulose fiber-based materials are ideal substitutes for traditional plastics. However, organic additives used to enhance water and oil resistance often contain toxic substances that may migrate into food, posing health risks. In this study, inspired by tree structures, lignin-containing cellulose nanofibers (LCNFs) are used to form a "crown-roots" structure to enhance the water, oil, and gas resistance, as well as mechanical performance of composites.
View Article and Find Full Text PDFNanoscale
January 2025
Ludwig-Maximilians-University, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstraße 5-13, Munich, 81377, Germany.
CRISPR-Cas9 has emerged as a highly effective and customizable genome editing tool, holding significant promise for the treatment of KRAS mutations in lung cancer. In this study, we introduce a novel micelleplex, named C14-PEI, designed to co-deliver Cas9 mRNA and sgRNA efficiently to excise the mutated KRAS allele in lung cancer cells. C14-PEI is synthesised from 1,2-epoxytetradecane and branched PEI 600 Da a ring-opening reaction.
View Article and Find Full Text PDFAnticancer Agents Med Chem
January 2025
Department of Histology and Embryology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Türkiye.
Objective: This study utilized three cell lines: normal prostate epithelial RWPE-1, androgen-dependent LNCaP, and androgen-independent PC3. We investigated the inhibitory effects of phenylboronic acid (PBA)'s inhibitory effect on cellular proliferation due to its ability to disrupt microtubule formation in prostate cancer cell lines. Additionally, this study aimed to assess the cytotoxic effects of PBA on prostate cancer cells using twodimensional (2D) and three-dimensional (3D) cell culture models.
View Article and Find Full Text PDFCurr Pharm Biotechnol
January 2025
Department of Pharmaceutical Chemistry and Analysis, Ramanbhai Patel College of Pharmacy, Charotar University of Science & Technology, CHARUSAT At- Changa, Dist- Anand, Ta- Petlad, Pin-388421.
Cancer treatment has evolved significantly over the years, incorporating a range of modalities including surgery, radiation, chemotherapy, and immunotherapy. However, challenges such as drug resistance, systemic toxicity, and poor targeting necessitate innovative approaches. Peptides have gained attention in cancer therapy due to their specificity, potency, and ability to modulate various biological pathways.
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