Histomorphology of ultimobranchial cysts of thyroid glands of sheep is presented. The average incidence of cysts in sheep was 17.3%. The cysts have some characteristic features indicating their ultimobranchial origin: the presence of inhomogeneous "foamy" colloid staining positively for glycosaminoglycans, heteromorphism of the cells lining the internal surface of the cysts, and the presence of ciliary cells among them. The detection of ultimobranchial cysts in sheep with strumous thyroid glands not only extends the concept of the species appurtenance of these formations but also indicates the possibility of frequent occurrence of ultimobranchial cysts in hyperplastic processes of strumous and neoplastic nature which is of great diagnostic and prognostic significance.
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J Vet Diagn Invest
January 2024
Departamento de Clínica Médica, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.
A 9-y-old Mangalarga Marchador gelding was referred to a veterinary hospital because of a swelling on the upper right side of the neck. Ultrasound examination revealed a multilocular structure adjacent to the thyroid gland with low echogenic content suggestive of fluid. The mass was removed surgically.
View Article and Find Full Text PDFPLoS One
March 2020
Section of Biological Safety Research, Tama Laboratory, Japan Food Research Laboratories, Tama, Tokyo, Japan.
Developmental anomalies of the thyroid gland lead to congenital malformations such as thyroglossal duct cysts and thyroid dysgenesis. However, the pathogenesis of thyroid dysgenesis remains unclear due to the lack of suitable animal models. This study demonstrated that Slc:Wistar/ST rats frequently developed unilateral thyroid dysgenesis, including hemiagenesis, characterized by the absence of one lobe.
View Article and Find Full Text PDFHistol Histopathol
June 2018
Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Pharyngeal pouches in mammals develop into specific derivatives. If the differentiation of the pharyngeal pouches is anomalous, their remnants can result in cysts, sinuses, and fistulae in the differentiated organs or around the neck. In the present study, we found several pharyngeal pouch remnants, such as cystic structures in thymus and parathyroid gland and fossulae extended from the piriform fossa, in the inbred cotton rats maintained at Hokkaido Institute of Public Health (HIS/Hiph) and University of Miyazaki (HIS/Mz).
View Article and Find Full Text PDFVirchows Arch
September 2017
Sikl's Department of Pathology, University Hospital Plzen, Medical Faculty in Plzen, Charles University in Prague, Edvarda Benese 13, Plzen, 305 99, Czech Republic.
There is a group of lesions in the head and neck region derived from branchial arches and related structures which, when inflamed, are characterized by the formation of cysts lined by squamous or glandular epithelium and surrounded by a heavy inflammatory infiltrate rich in germinal centers. In the thyroid, the main source of various structures which may cause diagnostic dilemma is the ultimobranchial body. To investigate the spectrum of such thyroid lesions, the consultation files were reviewed for thyroid samples containing pathological structures regarded to arise from the ultimobranchial body.
View Article and Find Full Text PDFHead Neck Pathol
March 2018
Department of Anatomic Pathology, University of Pittsburgh Medical Center, 3459 Fifth ave suite E-733, Pittsburgh, PA, USA.
Thyroglossal duct cysts (TGDCs) are present in ~7% of adults and develop from the midline migratory tract between the foramen cecum and anatomic location of the thyroid. Thyroid tissue can be identified in 2/3 of TGDCs, and up to 1% develop associated malignancy, 90% of which are papillary thyroid carcinoma. Cases of follicular and anaplastic carcinoma have been documented, but there are no reports of medullary thyroid carcinoma arising in a TGDC.
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