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Protective effects of myrtenol against paraquat-induced toxicity in rats.
BMC Pulm Med
January 2025
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, 7618868367, Iran.
Background: Paraquat (PQ) is a widely used pesticide, can cause severe intoxication and respiratory failure. Myrtenol (Mrl), an essential oil derived in various plants, exhibits several biological properties, including anti-inflammatory and antioxidant activities. This study aims to investigate the protective potential of Mrl against oxidative stress and inflammation caused by PQ exposure.
View Article and Find Full Text PDFAmeliorative Potential of Sudachitin Against Paraquat Induced Renal Toxicity in Rats Via Regulating Nrf2/Keap1 Pathway: An Inflammatory, Apoptotic and Histopathological Assessment.
Chem Biodivers
January 2025
Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, 38040, Pakistan.
Article Synopsis
- - The study tested the protective effects of thiocyanate (SCN) against paraquat (PQ)-induced kidney damage in albino rats, using four groups: control, PQ-only, PQ with SCN, and SCN-only.
- - PQ exposure decreased Nrf2 and its protective genes while increasing keap1, leading to reduced antioxidant enzyme activity and elevated markers of oxidative stress and kidney injury, such as MDA, ROS, and NGAL.
- - SCN treatment helped restore the harmful changes caused by PQ, demonstrating its potential benefits through its antioxidant, anti-inflammatory, and anti-apoptotic properties.
Factors associated with refusing hemoperfusion in patients with acute paraquat poisoning.
J Res Med Sci
July 2024
Department of Emergency, The Second Affiliated Hospital, Air Force Military Medical University, Xi'an, China.
Background: Paraquat poisoning remains a critical public health issue with no established effective treatment. Hemoperfusion (HP) has been recognized for its potential to remove toxins and is widely employed in several developing countries for managing acute paraquat poisoning cases. However, the reluctance of some patients to undergo this recommended treatment has been observed but not thoroughly investigated.
View Article and Find Full Text PDFSudachitin Alleviates Paraquat Instigated Testicular Toxicity in Albino Rats via Regulating Nrf-2/Keap-1, Inflammatory, Steroidogenic, and Histological Profile.
Environ Toxicol
December 2024
Texas A & M University, College Station, Texas, USA.
Paraquat (PQ) is a noxious herbicide which adversely affects the vital organs including male reproductive system. Sudachitin (SCN) is a naturally occurring flavonoid that demonstrates a wide range of biological potentials. The current study was designed to investigate the alleviative potential of SCN to avert PQ-induced testicular toxicity in rats.
View Article and Find Full Text PDFVascular endothelium, a promising target for effectively treating fulminant diquat intoxication?
World J Clin Cases
June 2024
Department of Critical Care Medicine, Dongguan Eastern Central Hospital, Dongguan 523576, Guangdong Province, China.
Article Synopsis
- Following the withdrawal of paraquat, diquat (DQ) has become the main herbicide, but it poses serious risks, including a poisoning mortality rate of up to 50%.
- DQ poisoning can range from mild to fulminant, the latter often leading to multiple organ failure within 48 hours, complicating clinical treatment.
- Research indicates that DQ may damage endothelial cells (EC), which are crucial for blood circulation in sensitive organs, and the authors suggest this EC damage could be a key factor in the severe organ failure associated with DQ poisoning.
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