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Evaluating CK20 and MCPyV Antibody Clones in Diagnosing Merkel Cell Carcinoma.
Endocr Pathol
January 2025
Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Millet Caddesi, Fatih, Istanbul, 34093, Turkey.
Merkel cell carcinoma (MCC) is diagnosed through histopathological and immunohistochemical examination of biopsies from skin or other organs. Its distinguishing features include perinuclear dot-like staining with Cytokeratin 20 (CK20) and detection of Merkel cell polyomavirus (MCPyV) using various methods. However, CK20 and MCPyV negative MCC cases have been reported at varying rates.
View Article and Find Full Text PDFAn integrated multiphase dynamic genome-scale model explains batch fermentations led by species of the genus.
mSystems
January 2025
Biosystems and Bioprocess Engineering, IIM-CSIC, Vigo, Spain.
During batch fermentation, a variety of compounds are synthesized, as microorganisms undergo distinct growth phases: lag, exponential, growth-no-growth transition, stationary, and decay. A detailed understanding of the metabolic pathways involved in these phases is crucial for optimizing the production of target compounds. Dynamic flux balance analysis (dFBA) offers insight into the dynamics of metabolic pathways.
View Article and Find Full Text PDFComparative metagenomics of tropical reef fishes show conserved core gut functions across hosts and diets with diet-related functional gene enrichments.
Appl Environ Microbiol
January 2025
School of Marine Science and Policy, University of Delaware, Lewes, Delaware, USA.
Unlabelled: Fish gut microbial communities are important for the breakdown and energy harvesting of the host diet. Microbes within the fish gut are selected by environmental and evolutionary factors. To understand how fish gut microbial communities are shaped by diet, three tropical fish species (hawkfish, ; yellow tang, ; and triggerfish, ) were fed piscivorous (fish meal pellets), herbivorous (seaweed), and invertivorous (shrimp) diets, respectively.
View Article and Find Full Text PDFAssociations between water exposure and the development of amyotrophic lateral sclerosis: a matched case-control study.
Amyotroph Lateral Scler Frontotemporal Degener
January 2025
Stan Cassidy Centre for Rehabilitation, Fredericton, New Brunswick, Canada.
Objective: Previous studies have hinted at an association between water exposure and the development of ALS. However, proximity measures to these water sources have been limited to questionnaires or large buffers due to a lack of fine geospatial measures. They also do not distinguish the various classes of hydrographic features.
View Article and Find Full Text PDFm6A Methylation Regulator RBM15-Mediated Upregulation of ITGBL1 mRNA Stability Aggravates Colon Adenocarcinoma Progression by Remodeling the Tumor Microenvironment.
Turk J Gastroenterol
January 2025
Department of Gastrointestinal and Thoracic Surgery, Jiulongpo People's Hospital, Chongqing, China.
Background/aims: Colon adenocarcinoma (COAD) is a prevalent malignant tumor of the digestive system. Previous research has indicated that RNA N6-methyladenosine (m6A) methyltransferase RNA-binding motif protein-15 (RBM15) is involved in various cancers. We aimed to investigate the function of RBM15 in COAD progression and its underlying molecular mechanism.
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