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Cannabis use patterns and different phenotypes in relation to other drugs use: latent class analyses from the Sao Paulo Megacity Mental Health Survey.
Braz J Psychiatry
March 2025
Núcleo de Epidemiologia Psiquiatrica - LIM 23, Departamento e Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Cannabis is the most widely used substance in Brazil. This study examined subtypes of individuals who use cannabis based on usage characteristics and correlates with other substance consumption and harms. Data are from the São Paulo Megacity Mental Health Survey (N = 5,037).
View Article and Find Full Text PDFParental pattern, childhood trauma, and impulsivity contribute to the severity of crack cocaine addiction: a cluster analysis.
Braz J Psychiatry
March 2025
Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Objective: To determine severity clusters (groups) of substance use in crack cocaine users by the severity scores of the sixth version of the Addiction Severity Index (ASI-6) and compare the groups detected in relation to risk factors as parental styles, childhood maltreatment, and impulsivity.
Methods: A cross-sectional study was conducted with 531 male adults with Substance Use Disorder, admitted to a hospital treatment unit for addiction in Southern Brazil. In order to detect more homogeneous groups of individuals, the approach used involves the K-means clustering using ASI-6 scores to create clusters or groups of individuals with similar severity in different areas.
Proteomics-driven discovery of LCAT as a novel biomarker for liver metastasis in colorectal cancer.
BMC Cancer
March 2025
Department of General Surgery, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning Province, China.
Background: This study aimed to identify molecular markers that influence liver metastasis in colorectal cancer (CRC) and assess their clinical relevance.
Methods: Proteomic analysis compared differential protein expression between CRC patients with liver metastasis (CRLM) and those without (CRNLM). Bioinformatics and survival analyses identified key proteins and validated them using the TCGA database for expression and clinical significance.
Inflammatory cytokines and oral cancer risk: an integrated study combining two-sample Mendelian randomization with experimental validation.
Discov Oncol
March 2025
The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, BaYi Road No. 463, DongHu District, NanChang, 330006, Jiangxi, China.
Objective: This study aimed to investigate the causal relationship between inflammatory cytokines and oral cavity cancer risk using Mendelian randomization analysis and experimental validation.
Methods: Two-sample Mendelian randomization was conducted using summary-level genome-wide association study data on 41 inflammatory cytokines and oral cavity cancer risk in Europeans. Single nucleotide polymorphisms associated with cytokines (p < 5 × 10-6) and oral cancer were selected as instrumental variables, excluding those in linkage disequilibrium.
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