AI Article Synopsis

  • 152 blood donors with anti-HBs were monitored for 2 to 9 years to track the persistence of this hepatitis-B marker.
  • The study indicates that controlled carriers maintain anti-HBs positivity for an average of at least 10 years.
  • A specific subset of these donors, identified as "hyperreactors," exhibit a unique immune response and demonstrate long-lasting high levels of anti-HBs.

Article Abstract

152 anti-HBs positive blood donors were observed for 2 to 9 years for persistence of this hepatitis-B marker. The results suggest an average persistence of anti-HBs-positive findings in the controlled carriers of at least 10 years. Some of the investigated blood donors belong to a special group of "hyperreactors" with long-lasting persistence of high-titred anti-HBs. These are apparently persons with a special immune reaction pattern.

Download full-text PDF

Source

Publication Analysis

Top Keywords

blood donors
8
[hepatitis virus
4
virus epidemiology
4
epidemiology degree
4
degree contamination
4
contamination hyperreactors]
4
hyperreactors] 152
4
152 anti-hbs
4
anti-hbs positive
4
positive blood
4

Similar Publications

Adenine base editor corrected ADPKD point mutations in hiPSCs and kidney organoids.

Adv Biotechnol (Singap)

June 2024

MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510275, China.

Autosomal dominant polycystic kidney disease (ADPKD) is a dominant genetic disorder caused primarily by mutations in the PKD1 gene, resulting in the formation of numerous cysts and eventually kidney failure. However, there are currently no gene therapy studies aimed at correcting PKD1 gene mutations. In this study, we identified two mutation sites associated with ADPKD, c.

View Article and Find Full Text PDF

Background: Single-cell RNA sequencing (scRNA-seq) has improved our ability to characterize rare cell populations. In practice, cells from different tissues or donors are simultaneously loaded onto the instrument (multiplexed) at the recommended (standard loading) or higher (superloading) numbers to save time and money. Although cost-effective, superloading can stymie computational analyses owing to high multiplet rates and sample complexity.

View Article and Find Full Text PDF

Although islet transplantation is effective in reducing severe hypoglycemia events and controlling blood glucose in patients with type 1 diabetes, maintaining islet graft function long-term is a significant challenge. Islets from multiple donors are often needed to achieve insulin independence, and even then, islet function can decline over time when metabolic demand exceeds islet mass/insulin secretory capacity. We previously developed a method that calculated the islet graft function index (GFI) and a patient's predicted insulin requirement (PIR) using mathematical nonlinear regression.

View Article and Find Full Text PDF

Erythropoiesis, a remarkably dynamic and efficient process responsible for generating the daily quota of red blood cells (approximately 280 ± 20 billion cells per day), is crucial for maintaining individual health. Any disruption in this pathway can have significant consequences, leading to health issues. According to the World Health Organization, an estimated 25% of the global population presents symptoms of anemia.

View Article and Find Full Text PDF

Background: Hepatitis B is a liver infection caused by HBV. Infected individuals who fail to control the viral infection develop chronic hepatitis B and are at risk of developing life-threatening liver diseases, such as cirrhosis or liver cancer. Dendritic cells (DCs) play important roles in the immune response against HBV but are functionally impaired in patients with chronic hepatitis B.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!