Echocardiography and the method of dye dilution (Evans blue) were used to study parameters of the central and intracardiac haemodynamics in 28 men with uncomplicated essential hypertension during treatment with diuretics. Tests were undertaken thrice: after a 5-6 day control period, after a 3-day furosemide load (120 mg per 24 hrs), after 2-3 weeks course of treatment with hypothiazide (50-100 mg per 24 hrs). As a result there was a decrease of end-systolic, end-diastolic and stroke volumes of the left ventricle. In patients with hypotensive effect minute volume did not diminish. In the group without effect there was no significant decrease of arterial pressure, minute volume and general peripheral resistance but an increase in the heart rate. The initial volumes of the circulating blood and plasma in both groups were indistinguishable and decreased significantly as a result of treatment.
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