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Insertion and Anchoring of the HIV-1 Fusion Peptide into a Complex Membrane Mimicking the Human T-Cell.
J Phys Chem B
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T-6 Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
A fundamental understanding of how the HIV-1 envelope (Env) protein facilitates fusion is still lacking. The HIV-1 fusion peptide, consisting of 15 to 22 residues, is the N-terminus of the gp41 subunit of the Env protein. Further, this peptide, a promising vaccine candidate, initiates viral entry into target cells by inserting and anchoring into human immune cells.
View Article and Find Full Text PDFMicroplastics in aquatic systems: A comprehensive review of its distribution, environmental interactions, and health risks.
Environ Sci Pollut Res Int
January 2025
Department of Environmental Science, University of Latvia, Jeglavas Street 1, Riga, LV-1004, Latvia.
Microplastics (MPs) have become a critical pollutant, accumulating in aquatic ecosystems and posing significant environmental and human health risks. Approximately 5.25 trillion plastic particles float in global oceans, releasing up to 23,600 metric tonnes of dissolved organic carbon annually, which disrupts microbial dynamics.
View Article and Find Full Text PDFHERV-W envelope protein is present in microglial cells of the human glioma tumor microenvironment and differentially modulates neoplastic cell behavior.
Microbes Infect
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Department of Neurology and Neurorehabilitation, Hospital Zum Heiligen Geist, Academic Teaching Hospital of the Heinrich-Heine-University Düsseldorf, Kempen, Germany. Electronic address:
Gliomas are the most common parenchymal tumors of the central nervous system (CNS). With regard to their still unclear etiology, several recent studies have provided evidence of a new category of pathogenic elements called human endogenous retroviruses (HERVs) which seem to contribute to the evolution and progression of many neurological diseases such as amyotrophic lateral sclerosis (ALS), schizophrenia, chronic inflammatory polyneuropathy (CIDP) and, particularly, multiple sclerosis (MS). In these diseases, HERVs exert effects on cellular processes such as inflammation, proliferation, and migration.
View Article and Find Full Text PDFExpression profiles of TNF-Alpha and HERV-K Env proteins in multiple types of colon and lung disease.
Genes Genomics
January 2025
Departments of Parasitology and Genetics, Kosin University College of Medicine, Busan, 49241, Republic of Korea.
Background: Human endogenous retroviruses (HERVs) were integrated into the human genome millions of years ago and have since proliferated to comprise about 8% of the human genome. For a long time, HERVs were thought to be remnants of ancient viruses, rendered inactive over the ages. However, recent studies have revealed that HERVs are involved in various diseases, including cancer.
View Article and Find Full Text PDFTrophic transfer effects of PS nanoplastics and field-derived nanoplastics in the freshwater clam Corbicula fluminea.
Aquat Toxicol
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Université de Bordeaux, UMR EPOC 5805, équipe Ecotoxicologie Aquatique, Station marine d'Arcachon, Place Du Dr Peyneau, 33120, Arcachon, France.
Plastic pollution is of global concern. Many studies investigated the effect of micro and nanoplatics towards aquatic organisms. However, relatively few studies were assessed on freshwater organisms.
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