AI Article Synopsis
- A study was conducted with 6 healthy volunteers to test the effects of alinidine, a new drug similar to clonidine, on stress-induced fast heart rates (tachycardia).
- Taking 40 mg of alinidine led to a slight 1% reduction in heart rate and lowered diastolic blood pressure during mental stress tasks.
- However, the drug did not significantly affect forearm blood flow or the participants' performance on the mental tasks.
Article Abstract
Experiments were performed in a randomized double-blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally-induced tachycardia. Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine.
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| http://dx.doi.org/10.1007/BF00542040 | DOI Listing |
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