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Calcification following tongue necrosis induced by vasopressor use in a nonintubated patient with septic shock: a case report.

J Med Case Rep

September 2024

Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Chungnam National University, 282 Munhwa-Ro, Jung-Gu, Daejeon, 35015, Republic of Korea.

Article Synopsis
  • Tongue necrosis is a rare condition often linked to issues like vasculitis or septic shock, which can lead to serious damage and calcification.
  • A case study details a 70-year-old man who experienced bilateral tongue necrosis after septic shock, with symptoms including discoloration and swelling, but without leg ischemia.
  • Successful treatment involved cleaning the affected area, highlighting the importance of regular tongue inspection during ICU care to catch complications early and reduce long-term damage.
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Background: Fahr's disease and syndrome are rare disorders leading to calcification of the small arteries in the basal ganglia of the brain, resulting in a wide range of symptoms comprising cognitive decline, movement disorders and neuropsychiatric symptoms. No disease-modifying therapies are available. Studies have shown the potential of treatment of ectopic vascular calcifications with bisphosphonates.

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Introduction: Coronary artery calcification (CAC) and especially progression in CAC is a strong predictor of acute myocardial infarction and cardiovascular mortality. Supplementation with vitamin K2 and D3 has been suggested to have a protective role in the progression of CAC. In this study, we will examine the effect of vitamins K2 and D3 in men and women with severe CAC.

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