The evidence of the pentagastrin rapid test inaugurated by Johnston and Jepson in contrast to the usual analysis of the gastric secretion (DAB 7 GDR) was controlled on altogether 256 patients. Of them 121 patients were examined according to the well-known method and 135 patients with the shortened pentagastrin test. The same efficiency could be verified for the pentagastrin rapid test. The stimulated acid secretion may be sufficiently exactly established with the help of this test for the daily practice and may be recommended for the use in the outpatient practice. The limits of the normal values established up to the existence of a sufficiently large number of test persons, a norm region of 3-25 mmol/h should be taken as a basis.
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Int J Pept Res Ther
September 2020
ToxiVen Biotech, Siva Nagar, Kovaipudur, Tamil Nadu 641042 India.
At the end of December 2019, a new strain of coronavirus was identified in the Wuhan city of Hubei province in China. Within a shorter period of time, an unprecedented outbreak of this strain was witnessed over the entire Wuhan city. This novel coronavirus strain was later officially renamed as COVID-19 (Coronavirus disease 2019) by the World Health Organization.
View Article and Find Full Text PDFEur J Pharmacol
July 2008
GI Research, Neurology & GI Centre of Excellence of Drug Discovery, GlaxoSmithKline, Harlow, Essex, UK.
Identification of novel drug molecules requires the extensive evaluation in vitro and in vivo. Following in vitro evaluation it is necessary to efficiently screen numerous novel molecules in vivo using relatively simple methodology that requires small numbers of animals, is rapid to perform, and provides results that can definitely discriminate potential candidates for further investigation. Herein, we describe the results of three standard compounds (omeprazole, a proton pump inhibitor; cimetidine, an histamine H(2) receptor antagonist; and AR-H047108, a potassium competitive acid blocker) in the rat aspiration model (under both basal and stimulated conditions), and compared the effects with those in the pyloric ligation model with a view to comparing the results in terms of sensitivity, robustness and simplicity of the methodology.
View Article and Find Full Text PDFSante
January 2008
Centre médical Marc Sankalé, BP 5062, Fann Dakar, Sénégal.
Various studies of medullary thyroid carcinoma have found its apoptosis rate to be very low. Tumor growth is usually progressive but in some cases, rapid progression and high proliferation are seen. Some mutations of the RET proto-oncogene are thought to have a direct or indirect effect on this clinical process.
View Article and Find Full Text PDFElectrophoresis
September 2007
Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety (Fuzhou University), Department of Chemistry, Fuzhou University, Fuzhou, Fujian, PR China.
A new method for the determination of the peptide hormones of brain and intestine based on CE coupling with a DAD and ESI-MS was established. Several electrophoretic and ESI-MS parameters were investigated in detail, such as electrolyte nature and concentration, organic solvent and sheath liquid compositions, nebulization gas pressure and the ESI capillary voltage. Optimized conditions were achieved with 25 mM formic acid-ammonium formate (pH 2.
View Article and Find Full Text PDFEncephale
March 2005
Service de Psychiatrie d'Adultes, (Professeur Tignol) Université Victor-Segalen Bordeaux 2, Centre Hospitalier Charles-Perrens, Centre Carreire, 121, rue de la Béchade, 33076 Bordeaux.
Social phobia (also known as social anxiety disorder) is still not clearly understood. It was not established as an authentic psychiatric entity until the diagnostic nomenclature of the American Psychiatric Association DSM III in 1980. In recent years, increasing attention among researchers has contributed to provide important information about the genetic, familial and temperamental bases of social phobia and its neurochemical, neuroendocrinological and neuroanatomical substrates, which remain to be further investigated.
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