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The objective of the present study was to clarify the characteristic pathognomonic features of middle ear lesions associated with tuberculosis and the approaches to their diagnostics under the present-day conditions. The study included 11 cases (18 ears) of tuberculosis otitis media and the related lesions of the mastoid process diagnosed with the use of clinical, roentgenological, cytological, bacteriological, pathomorphological, and molecular-genetic methods (including PCR diagnostics). The primary localization of tuberculosis in the middle ear was documented in 6 patients; in 5 patients, it was associated with pulmonary involvement.

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The respiratory system is the target organ of many autoimmune collagen diseases. In patients with Sjögren's syndrome (SS), the respiratory disorders are also common manifestations. Tracheal and pleural manifestations have been described (Strimlan 1976; Constantopoulos 1985).

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Similarity of clinical, roentgenological and even morphological features of tuberculosis and sarcoidosis causes difficulties in differential diagnosis. This necessitates searching for new diagnostic criteria. Comparative study of functional state of peripheral blood neutrophils and their reaction to specific antigens (tuberculin and Kveim's reagent) were studied in patients with disseminated tuberculosis and pulmonary sarcoidosis.

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17 cases with bronchial carcinoid were reported. 16 cases of them were proved pathologically after pulmonary resection, and the remaining one was confirmed histopathologically through bronchoscopic biopsy. 64.

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The authors describe the clinical, roentgenological findings, especially the oral manifestation and differential diagnosis of histiocytosis X in 23 cases. It is shown that the clinical and roentgenological differential diagnosis is problematically.

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