The present study was performed to evaluate clinically the therapeutic efficacy of human anti-tetanic globulin in established cases of tetanus. The study was conducted in 100 patients in India with tetanus receiving treatment at P.B.M. Hospital, Bikaner. The human anti-tetanic globulin was given in addition to equine anti-tetanic serum, to all those patients who could afford to purchase the same, irrespective of age, sex or the severity of the disease, during the period of study. Except for the administration of human anti-tetanic globulin, the management of all the patients was identical. The study revealed that human anti-tetanic globulin is effective for patients with a short period of onset. Patients having prolonged spasms at frequent intervals were also the beneficiaries, to some extent. The hospitalization period of all the patients receiving human anti-tetanic globulin was shortened.
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