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Flavones isolated from with tracheal smooth muscle relaxant properties.
Nat Prod Res
January 2024
National Center for Natural Products Research, School of Pharmacy, University of MS, University, MS, USA.
The inflorescences of are used as folk medicine to treat various respiratory diseases. In this work, we report the isolation of seven known flavones: 5-hydroxy-3,7-dimethoxyflavone , 5,8-dihydroxy-3,7-dimethoxyflavone , 5,7-dihydroxy-3,8-dimethoxyflavone (gnaphaliin A), 3,5-dihydroxy-7,8-dimethoxyflavone (gnaphaliin B), 3,5-dihydroxy-6,7,8-trimethoxyflavone , 3,5,7-trimethoxyflavone and 3--methylquercetin . All these flavones except and showed a relaxant effect on guinea pig tracheal preparation with EC between 69.
View Article and Find Full Text PDF[Effect of Xingnaojing Injection in treatment of cerebral hemorrhage based on Tabu search algorithm:a real world study].
Zhongguo Zhong Yao Za Zhi
July 2020
School of Statistics, Renmin University of China Beijing 100872, China.
In this study, Tabu search algorithm was used to analyze the effect of Xingnaojing Injection in the treatment of cerebral hemorrhage in the real world. Through the analysis of the results, the therapies based on the pathogeny of cerebral hemorrhage were screened out: Xingnaojing Injection+hemostatic drugs for promoting blood circulation and removing stasis. Cerebral hemorrhage complicated with brain edema: combined with mannitol or mannitol+aescin.
View Article and Find Full Text PDFRelaxant effect of Lippia origanoides essential oil in guinea-pig trachea smooth muscle involves potassium channels and soluble guanylyl cyclase.
J Ethnopharmacol
June 2018
Pós-graduação em Recursos Naturais do Semiárido, Universidade Federal do Vale do São Francisco (UNIVASF), Brazil; Colegiado de Farmácia, Universidade Federal do Vale do São Francisco (UNIVASF), Brazil. Electronic address:
Ethnopharmacological Relevance: Lippia origanoides H.B.K.
View Article and Find Full Text PDFRelaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase.
Eur J Pharmacol
September 2017
Department of Pharmacology, College of Medicine, Taipei Medical University, 250 Wu-Hsing St., Taipei 110, Taiwan. Electronic address:
Apigenin, was reported to have vasodilatory effects by inhibiting Ca influx through both voltage- and receptor-operated calcium channels, but not by inhibiting cAMP- or cGMP-phosphodiesterases (PDEs) in rat thoracic aorta. However, apigenin was reported to inhibit PDE1, 2 and 3 in guinea-pig lung and heart. The aim of this study was to clarify that guinea-pig tracheal relaxation by apigenin whether via PDE inhibition.
View Article and Find Full Text PDFGaletin 3,6-dimethyl ether (FGAL), a flavonoid from the aerial parts of Piptadenia stipulacea (Benth.) Ducke, was found to exert a relaxant effect on carbachol (CCh)-pre-contracted guinea-pig trachea. Based on cumulative concentration-response curves to CCh, FGAL antagonized muscarinic receptors pseudo-irreversibly and noncompetitively, since it inhibited and shifted these curves towards higher concentrations in a nonparallel manner.
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