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A Rare Case of Clofazimine-induced Pigmentary Enteropathy.
J Pediatr Gastroenterol Nutr
August 2021
Department of Pediatric Gastroenterology and Hepatology, B J Wadia Hospital for Children, Mumbai. India.
Clofazimine Enteropathy: A Rare and Underrecognized Complication of Mycobacterial Therapy.
Open Forum Infect Dis
September 2016
Infectious Diseases.
Article Synopsis
- - Clofazimine, a medication used for leprosy, can cause a rare side effect called crystal-storing histiocytosis, which has mostly been discussed in dermatology.
- - A specific case involved a patient treated with high doses of oral clofazimine who developed serious symptoms, including abdominal pain, malnutrition, and melena (bloody stools).
- - The treatment led to enteropathy, an intestinal disorder, highlighting the potential severe complications of clofazimine therapy beyond its intended dermatological use.
Clofazimine-induced enteropathy in a patient of leprosy.
Indian J Pharmacol
January 2014
Department of Pharmacology, Guru Gobind Singh Medical College, Faridkot, Punjab, India.
Clofazimine-induced crystal-storing histiocytosis is a rare but well-recognized condition reported in literature. In addition to common reddish discoloration of the skin, clofazimine produces gastrointestinal disorder, sometimes severe abdominal pain. Also, the pathologic and radiologic findings can produce diagnostic difficulties if the pathological changes caused by it are not known.
View Article and Find Full Text PDFClofazimine-induced enteropathy in treatment-resistant nodular vasculitis.
Australas J Dermatol
May 2012
Department of Dermatology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
Article Synopsis
- * The introduction of oral clofazimine at 300 mg daily allowed for a significant reduction in prednisolone dosage to 22.5 mg and completely suppressed the disease activity.
- * However, after nearly two years of successful treatment, the patient experienced clofazimine-induced enteropathy, leading to the discontinuation of the drug which resulted in a flare of the vasculitis, highlighting the need for caution and awareness of potential side effects when using clofazimine.
[Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy].
Biomedica
March 2009
Grupo de Microbiología Molecular, Facultad de Medicina, Universidad de La Sabana, Chía, Cundinamarca.
Introduction: Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum. Objective. A woman is presented who had a delayed diagnosis of leprosy, persistent type 2 lepra reaction and lethal clofazimine enteropathy.
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