Fibroblasts derived from human foetal tendon, skin and lung were cultured in media containing dissolved oxygen at concentrations of 20%, 10% and 2.7%. Total protein and collagen synthesis were reduced at 2.7% oxygen, tendon-derived cells proving significantly less sensitive than lung and skin fibroblasts. The effects of hypoxia were more marked in low-density cultures than in confluent cultures. Proliferation rates varied greatly between the 3 cell lines but were not affected by hypoxia. The implications of these results with respect to tendon degeneration and rupture are discussed.
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