The rabbit serves as the only existing experimental model for ocular toxoplasmosis. This model has many deficiencies. Our technique for the production of acute toxoplasmic retinitis in monkeys is described herein. This primate model should be more representative than the rabbit model of human ocular toxoplasmosis.

Download full-text PDF

Source
http://dx.doi.org/10.1001/archopht.1982.01030030323021DOI Listing

Publication Analysis

Top Keywords

ocular toxoplasmosis
12
experimental ocular
4
toxoplasmosis primates
4
primates rabbit
4
rabbit serves
4
serves existing
4
existing experimental
4
model
4
experimental model
4
model ocular
4

Similar Publications

Congenital toxoplasmosis in infants from chronically infected mothers: report of two cases.

Rev Paul Pediatr

January 2025

Universidade Federal de Goiás, Institute of Tropical Pathology and Public Health, Parasite-Host Relationship Studies Laboratory, Goiânia, GO, Brazil.

Objective: To describe two severe cases of congenital toxoplasmosis in infants born to chronically infected mothers who did not receive education or information on the prevention of gestational toxoplasmosis during prenatal care.

Case Description: The mothers had a previous serological diagnosis of toxoplasmosis conducted during prenatal care, with non-reactive (<10 IU/mL) IgM and reactive IgG (>10 IU/mL), and were considered "immune" to the infection. Both infants were born with sequelae of the congenital infection, including neurological and ocular alterations.

View Article and Find Full Text PDF

Objective: Ocular toxoplasmosis, caused by , is a significant cause of posterior uveitis and vision impairment globally. Accurate diagnosis is essential to prevent retinal damage and optimise treatment. This study aimed to compare three diagnostic methods funduscopy, serology (ELISA), and PCR in detecting ocular toxoplasmosis in patients at ECWA Eye Hospital, Kano, Nigeria.

View Article and Find Full Text PDF

Construction and biological function of gene knockout strain.

Zhong Nan Da Xue Xue Bao Yi Xue Ban

August 2024

Department of Parasitology, School of Basic Medical Sciences, Central South University, Changsha 410013.

Objectives: Toxoplasmosis is a zoonotic parasitic disease caused by (), which can lead to complications such as encephalitis and ocular toxoplasmosis. The disease becomes more severe when the host's immune system is compromised. Rhoptry proteins are major virulence factors that enable to invade host cells.

View Article and Find Full Text PDF

Ocular toxoplasmosis is the leading cause of infectious retinochoroiditis in both adults and children. It is caused by the obligate intracellular parasite, Toxoplasma gondii. It is a common cause of posterior uveitis and focal retinitis, typically seen in immunocompetent individuals as a primary infection or in immunocompromised individuals as reactivation of latent infection.

View Article and Find Full Text PDF

Toxoplasma gondii from Gabonese forest, Central Africa: First report of an African wild strain.

PLoS Negl Trop Dis

January 2025

Inserm U1094, IRD UMR270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of Chronic Diseases in Tropical Zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.

The protozoan Toxoplasma gondii is a ubiquitous and highly prevalent parasite that can theoretically infect all warm-blooded vertebrates. In humans, toxoplasmosis causes infections in both immunodeficient and immunocompetent patients, congenital toxoplasmosis, and ocular lesions. These manifestations have different degrees of severity.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!