[Effect of vagotomy on the formation and development of a chronic experimental (acetate) ulcer of the duodenum in rats].

Bilateral subdiaphragmatic truncal vagotomy done either 11 days before or 10 days after induction of an acetic (Okabe's modification) duodenal ulcer in rats results in acceleration of the process of its spontaneous healing. The time of epithelization shortens, reduction of connective tissue growth is accelerated, contraction of tissues around the ulcer intensified, tunica muscularis regenerates almost completely. At the same time there are some alterations in the processes of formation at the site of the ulcer: newly forming villi are smaller than in control rats, they have abnormal configuration; newly forming duodenal glands often undergo cystic extension.