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F-ASEM PET/MRI targeting alpha7-nicotinic acetylcholine receptor can reveal skeletal muscle denervation.
EJNMMI Res
January 2024
Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
Article Synopsis
- The study investigates the increased expression of nicotinic acetylcholine receptors (nAChR) in muscles after nerve injury, focusing on the F-ASEM radiotracer as a diagnostic tool for visualizing muscle denervation in mice following sciatic nerve resection.
- Mice were evaluated at one and three weeks post-denervation using F-ASEM PET/MRI imaging, measuring the uptake in the affected muscles compared to the control side, with results indicating significantly higher uptake in denervated muscles.
- Additional analyses, including autoradiography and immunohistochemistry, confirmed increased alpha7-nAChR expression in denervated muscles, while a blocking study indicated that when blocked, the F-ASEM
The Neuroanatomical Basis of the 5-HT Syndrome and Harmalineinduced Tremor.
Curr Rev Clin Exp Pharmacol
January 2024
University of Lorraine, Laboratory of Stress, Immunity, Pathogens (EA7300), Medical School, 54500 Vandoeuvre-les- Nancy, France.
The 5-HT syndrome in rats is composed of head weaving, body shaking, forepaw treading, flat body posture, hindlimb abduction, and Straub tail. The importance of the brainstem and spinal cord for the syndrome is underlined by findings of 5,7-dihydroxytryptamine (5,7-DHT)-induced denervation supersensitivity in response to 5-HT-stimulant drugs. For head weaving and Straub tail, supersensitivity occurred when the neurotoxin was injected into the cisterna magna or spinal cord, for forepaw treading in cisterna magna, and for hindlimb abduction in the spinal cord.
View Article and Find Full Text PDFSevere blood pressure elevation following ephedrine administration during carotid endarterectomy under general anesthesia: A CARE-compliant case report.
Medicine (Baltimore)
March 2023
Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Rationale: During carotid endarterectomy (CEA) surgery, blood pressure management is particularly important to prevent cerebrovascular and cardiac complications. Ephedrine is a commonly used vasopressor, however, we report the case of a patient with unusually severe blood pressure elevation following intravenous ephedrine administration during CEA.
Patient Concerns: A 72-year-old man diagnosed with right proximal internal carotid artery stenosis underwent CEA under general anesthesia.
Dilute pilocarpine test for diagnosis of Adie's tonic pupil.
Sci Rep
May 2021
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam, Gyeonggi-do, 13620, Korea.
We have compared the diagnostic ability of different concentrations of 0.125% and 0.0625% dilute pilocarpine for detecting denervation supersensitivity in unilateral Adie's tonic pupil.
View Article and Find Full Text PDFOphthalmic and Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 (COVID-19).
Ocul Immunol Inflamm
November 2020
Department of Ophthalmology, Hospital Universitari Doctor Peset, Valencia, Spain.
Purpose: To describe a case of inflammatory chorioretinopathy and Adie's syndrome possibly associated with COVID-19.
Methods: Observational case report.
Results: A 51-year-old woman developed fever, cough, and headache followed by retro-ocular pain and reading impairment.
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