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Activation of the HIF1α/TIMP1/MT6-MMP pathway is associated with invasion in pituitary null cell adenomas.
Endocr Relat Cancer
December 2024
C Mu, Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Non-functioning pituitary adenomas (NFPAs) are a highly heterogeneous group and often shows invasion, but few studies have explored the invasion mechanism and biomarkers for specific subtypes. This study was designed to describe the role of HIF1α and its downstream genes in specific subtypes of NFPAs. Specimens were classified into two subtypes of NFPAs: 46 null cell adenomas (28 invasive, 18 non-invasive) and 46 oncocytomas (11 invasive, 35 non-invasive).
View Article and Find Full Text PDFPituitary spindle cell oncocytoma: Two cases report and literature review.
Int J Surg Case Rep
November 2024
Department of Pathology, Chang Gung Memorial Hospital, Linkou Center, Taoyuan City, Taiwan.
Introduction: Pituitary spindle cell oncocytoma (PSCO) is a seldom-encountered type of pituitary neoplasm with distinctive histological features. It was first described as a distinct entity by Roncaroli et al. in 2002.
View Article and Find Full Text PDFAdrenal Oncocytoma: A Rare Tumor with Conflicting Imaging Features.
J Nucl Med Technol
December 2024
Department of Nuclear Medicine, All India Institute of Medical Sciences, Bhubaneswar, India.
Oncocytic adenomas are rare benign tumors that typically originate in organs such as the kidneys, thyroid, parathyroid, salivary glands, or pituitary gland. Oncocytic adenoma of the adrenal gland is extremely rare. It often shows heterogeneous, nonspecific features on anatomic imaging, as well as high F-FDG avidity despite its benign nature.
View Article and Find Full Text PDF[ germline mutation-associated pheochromocytoma-paraganglioma syndrome: multiple endocrine neoplasia type 5].
Zhonghua Wai Ke Za Zhi
August 2024
Department of Emergency and Critical Medicine, Tiantai People's Hospital of Zhejiang Province, Taizhou 317200, China.
The individualized precision management of hereditary pheochromocytoma (PHEO) and paraganglioma (PGL) syndromes (PPGLs) based on molecular diagnosis and molecular subtype is becoming more popular. The newly discovered germline mutation-associated PPGLs are autosomally dominant and rare. To raise awareness and explore the effective management of individual diagnosis and treatment, the relevant literature published between January 2011 and February was systematically reviewed.
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