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High BMP7 Expression May Worsen Airway Disease in COPD by Altering Epithelial Cell Behavior.
Int J Chron Obstruct Pulmon Dis
January 2025
Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Purpose: Airway disease is the main pathological basis of chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are unknown. Bone morphogenetic protein-7 (BMP7) is a multi-functional growth factor that belongs to the transforming growth factor superfamily, which affects the regulation of proliferation, differentiation, and apoptosis. Previous research has shown that BMP7 is highly expressed in the airway epithelia of patients with COPD, but its role in airway disease has not been fully elucidated.
View Article and Find Full Text PDFDiagnostic Dilemma: Investigating Respiratory Symptoms in a Middle-Aged Smoker.
Clin Case Rep
November 2024
Clinical Research Development Unit, Afzalipour Hospital Kerman University of Medical Sciences Kerman Iran.
Article Synopsis
- - A 65-year-old man presented with severe symptoms like fever, chest pain, and hemoptysis, which led doctors to initially suspect pulmonary thromboembolism or pneumonia.
- - After further testing, he was diagnosed with acute necrotizing granulomatous bronchitis, pointing to endobronchial tuberculosis (TB), highlighting the need to consider TB in patients with ongoing respiratory issues.
- - Treatment involves starting multidrug antitubercular therapy, monitoring the patient closely, implementing infection control, and educating him about the illness, which is crucial for better health outcomes and managing TB effectively.
[Chemical pneumonia caused by inhalation of waterproofing spray: a case report].
Zhonghua Jie He He Hu Xi Za Zhi
November 2024
Department of Pulmonary and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing 100730, China.
Article Synopsis
- A 23-year-old man developed chemical pneumonia after using waterproofing spray in a confined space, experiencing cough, chest tightness, and fever.
- His tests revealed elevated white blood cell counts and hypoxemia, while imaging showed diffuse ground-glass opacities in both lungs.
- Treatment with intravenous methylprednisolone led to significant improvement in symptoms and resolution of lung opacities, highlighting the need for proper diagnosis and treatment in similar cases.
A Rare Case of Tracheal Schwannoma Successfully Treated With Endoscopic Resection and Cryoablation Under Rigid Bronchoscopy.
Case Rep Pulmonol
October 2024
Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China.
Article Synopsis
- Case of a 54-year-old woman in Hong Kong with a rare tracheal schwannoma leading to respiratory issues; diagnosis was challenging due to rarity.
- The emergency treatment involved rigid bronchoscopy and cryoablation, successfully removing the tumor and reducing its size in follow-up checks over 3.5 years.
- The case underscores the importance of considering tracheal tumors in patients with unexplained breathing problems, and highlights the effectiveness of endoscopic techniques for diagnosis and treatment.
Combining high-flow nasal cannula oxygen therapy with repeated toilet bronchoscopies for respiratory failure due to excessive infected airway secretions: a case report and series from a non-intensive hospital ward.
Front Med (Lausanne)
September 2024
Unit of Geriatrics, Azienda Ospedaliero-Universitaria Renato Dulbecco, Catanzaro, Italy.
Article Synopsis
- * Non-invasive ventilation (NIV) and high-flow nasal cannula oxygen therapy (HFNC) provide necessary respiratory support during these procedures.
- * A successful case study involving a 78-year-old patient with ARF showed that combining HFNC with multiple FBOs improved his condition and allowed similar treatments for other ARF patients, suggesting this combination could be a safe alternative to intubation in elderly patients facing severe airway obstruction.
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