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Aim: To study the role of iodine, selenium and zinc in the pathogenesis of iodine deficiency and autoimmune thyroid diseases and scientifically substantiate the choice of security biomarkers and analytical methods for determination.
Materials And Methods: Serum iodine (I), selenium (Se), and zinc (Zn) concentrations were measured using inductively coupled plasma ionization tandem mass spectrometry (Agilent 8900 ICP-MS Triple Quad); by chemiluminescent immunoassay on an automatic analyzer Architect i2000 - TSH and AT-TPO in blood serum; by enzyme immunoassay - ZnT8A; biochemical method - ALP, SOD1 in 1150 people aged from 18 to 65 years (the average age of the subjects was 40±5 years). Ultrasound of the thyroid gland was performed in the supine position using a portable ultrasound machine LOGIQe with a multifrequency linear sensor 10-15 MHz; during the study, the volume of the thyroid gland, the presence of nodules and their characteristics according to the TIRADS classification, the structure of the thyroid gland and its echogenicity were assessed.
Cryoprotective effect of zinc and gold nanoparticles during cooling and freeze-thawing on Marwari stallion sperm parameters and reactive oxygen species production.
Cryo Letters
March 2025
College of Veterinary and Animal Sciences, Bikaner, Rajasthan, India.
Background: Sperm cryopreservation is one of the most important procedures in the development of biotechnologies for assisted reproduction. Cryopreservation of stallion spermatozoa tends to cause plasma membrane damage due to the low ratio of cholesterol to phospholipids. Different substances and compounds can be added to semen extenders to improve sperm quality.
View Article and Find Full Text PDFFunctional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation.
J Nanobiotechnology
March 2025
Fujian Key Laboratory of Flexible Electronics, Strait Laboratory of Flexible Electronics (SLoFE), Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Normal University, Fuzhou, Fujian, 350117, China.
Elevated copper levels induce tumor cuproptosis and ferroptosis, leading to immunogenic cell death and subsequent antitumor immune responses. However, dysregulated copper metabolism in tumor cells maintains homeostatic copper balance, while hypoxic microenvironments hinder therapeutic efficacy. In this study, we present a nanozyme system, termed CussOMEp, comprising a copper-based nanovector (CussNV) that is PEGylated and loaded with omeprazole, a copper transporter inhibitor, to enhance tumor synergistic immunotherapy by promoting cuproptosis and ferroptosis.
View Article and Find Full Text PDFAssociations between serum ferritin levels and gestational diabetes mellitus among a non-anemic population.
BMC Pregnancy Childbirth
March 2025
Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd #1, Hangzhou, Zhejiang Province, 310006, China.
Background: Studies have shown a strong correlation between excess iron and the development of gestational diabetes mellitus (GDM), though iron is an essential trace element during pregnancy. This study aims to investigate the precise relationship between iron storage levels during late pregnancy and the development of GDM, trying to find out ways to meet pregnant iron storage requirements and reduce GDM risk simultaneously.
Methods: A non-anemic population consisting of 9,512 healthy singleton pregnant women were included in this study.
Effect of Mn content on the corrosion behavior and biocompatibility of biodegradable Zn-Mn alloys.
Sci Rep
March 2025
School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Zinc-based alloys have attracted increasing attention as biodegradable metals by virtue of their excellent mechanical, degradable and biocompatible properties. By introducing different levels of manganese (0.1, 0.
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