The estimation of mimosine and 3-hydroxy-4(1H)-pyridone in Leucaena leucocephala, Leucaena seeds, chick excreta and chick serum using reversed-phase ion-pair high-performance liquid chromatography was investigated. Isocratic elution of both compounds was achieved in 11 min using sodium octyl sulphate as the pairing agent in a pH 2.25 buffer. Good recoveries of both mimosine and 3-hydroxy-4(1H)-pyridone in all but serum samples were obtained.
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