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Influence of Warfarin Therapy on Prothrombin Production and Its Posttranslational Modifications.
J Appl Lab Med
November 2020
Department of Laboratory Medicine, Tenri Hospital, Nara, Japan.
Background: Protein induced by vitamin K absence-II (PIVKA-II) is produced by the liver during hepatoma and upon warfarin administration. Those patients have disturbed protein synthesis and glycosylation in the liver. This decreases the number of γ-carboxyglutamyl (Gla) residues on prothrombin, converting prothrombin into PIVKA-II.
View Article and Find Full Text PDFThe present study was undertaken to elucidate the effect on platelet aggregation of the prothrombin-converting reaction on platelets with or without activated protein C (APC). A reaction mixture of washed platelets from human individuals, Factor Xa and prothrombin markedly induced platelet aggregation; maximum aggregation rates, 31.3-92.
View Article and Find Full Text PDFThe anticoagulant mechanism of action of recombinant hirudin (CGP 39393) in plasma.
Thromb Haemost
November 1990
Department of Biochemistry, University of Limburg, Maastricht, The Netherlands.
We studied the inhibitory action of recombinant desulphatohirudin (CGP 39393) on thrombin generation in whole plasma. Human plasma was activated either with thromboplastin or factor IXa. Hirudin delayed thrombin generation, but it was unable to prevent the explosive appearance of thrombin.
View Article and Find Full Text PDFAntithrombin III-dependent anti-prothrombinase activity of heparin and heparin fragments.
J Biol Chem
June 1989
Department of Biochemistry, University of Limburg, Maastricht, The Netherlands.
Heparin and heparin fragments in the molecular mass range 1,700-20,000 Da were examined for their ability to accelerate the antithrombin III (AT III)-dependent inhibition of human factor Xa and the prothrombin converting complex (prothrombinase) during human prothrombin activation. The prothrombinase reaction was modeled by a 3-parameter 2-exponential equation to determine the initial rate of prothrombin activation and the pseudo-first order rate constants of inhibition of prothrombinase and in situ generated thrombin activity. The catalytic specific activities of the heparins increased with increasing molecular size for both the inhibition of prothrombinase and factor Xa.
View Article and Find Full Text PDFWe have investigated the antithrombin III independent effect of crude heparin, two heparin fractions and a heparinoid on in vitro thrombin-induced platelet activation. Thrombin-induced platelet factor Va generation and thrombin plus collagen-induced platelet prothrombin converting activity were tested. Crude heparin was a more potent inhibitor of these reactions than the fractions or the heparinoid.
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