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Dietary Recommendations for Familial Hypercholesterolaemia: an Evidence-Free Zone.
BMJ Evid Based Med
December 2021
Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
We have evaluated dietary recommendations for people diagnosed with familial hypercholesterolaemia (FH), a genetic condition in which increased low-density lipoprotein cholesterol (LDL-C) is associated with an increased risk for coronary heart disease (CHD). Recommendations for FH individuals have emphasised a low saturated fat, low cholesterol diet to reduce their LDL-C levels. The basis of this recommendation is the 'diet-heart hypothesis', which postulates that consumption of food rich in saturated fat increases serum cholesterol levels, which increases risk of CHD.
View Article and Find Full Text PDFThe concept of a multiple risk-factor intervention trial (MRFIT) originated in mid-20th century efforts to determine whether modifying the "risk factors" established by cardiovascular disease epidemiology would prevent heart attacks. The term "MRFIT" probably first appeared in the 1968 report to the National Heart Institute from investigators of the National Diet-Heart Feasibility Study. Based on their pilot experience, they recommended a trial of diet alone.
View Article and Find Full Text PDFRationale of the diet-heart statement of the American Heart Association. Report of the Nutrition Committee.
Circulation
December 1993
Office of Scientific Affairs, American Heart Association, Dallas, TX 75231-4596.
A commentary on the Rationale of the Diet-Heart Statement of the American Heart Association.
Am J Clin Nutr
September 1984
The objective of the Rationale of the Diet-Heart Statement of the American Heart Association was to restate the diet-heart recommendations of the American Heart Association and to quote the original publications on which they are based. Examination of those publications reveals that for the most part, they are obsolete or misquoted. The last section of the Rationale concerns the role of genetics and very briefly reviews the epidemiological and dietary intervention trial evidence.
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