AI Article Synopsis
- A histochemical technique was used to detect androgen binding in prostatic cancer across 108 patient specimens, compared with a biochemical method in a double-blind study involving 77 patients.
- Statistical analysis revealed a strong agreement between the two methods regarding the qualitative and quantitative presence of androgen binding and its localization in cell components.
- While the sample size for evaluating clinical response was small (20 patients), there was a notable correlation between histochemical results and patient responses to hormonal treatment, though no link was found between androgen binding and tumor grade or disease stage.
Article Abstract
A histochemical technique for the detection of androgen binding in prostatic cancer was performed on specimens from 108 patients and compared with a biochemical method in a double blind study of 77. Statistical analyses showed a significant agreement between the two assay systems for the qualitative and quantitative presence or absence of specific androgen binding, as well as for the subcellular localization of binding in nucleus and/or cytoplasm. Although the number of cases studied was too small for statistical analysis, there appeared to be good correlation between histochemical androgen binding results and clinical response, or lack of response to hormonal manipulation in 20 patients with State C and Stage D carcinoma. No correlation was evident between androgen binding and tumor grade or clinicopathologic stage of disease of either histochemistry or biochemistry.
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| http://dx.doi.org/10.1002/1097-0142(19820301)49:5<984::aid-cncr2820490523>3.0.co;2-p | DOI Listing |
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