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Maximizing phonation: impact of inspiratory muscle strengthening on vocal durations and pitch range.

BMC Pulm Med

January 2025

Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.

Background: This study investigated the acute effects of inspiratory muscle warm-up (IWU) on vocal performance in singers. Proper vocal and respiratory warm-up can enhance vocal range, quality, and endurance. The aim was to determine whether IWU improves maximum phonation time and pitch range, contributing to better voice production efficiency (vocal efficiency) and reduced fatigue.

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Assessing Lung Ventilation and Bronchodilator Response in Asthma and Chronic Obstructive Pulmonary Disease with F MRI.

Radiology

December 2024

From the Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom (B.J.P., M.A.N., C.W.H., A.J.S., P.E.T.); Newcastle Magnetic Resonance Centre, Health Innovation Neighbourhood, Newcastle University, Newcastle upon Tyne NE4 5PL, United Kingdom (B.J.P., M.A.N., C.W.H., P.E.T.); Pulmonary, Lung and Respiratory Imaging Sheffield, Section of Medical Imaging and Technologies, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom (A.M.M., J.M.W.); Department of Respiratory Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom (I.F.); Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom (R.A.L.); Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom (H.F.F., J.N.S.M.); and Insigneo Institute, University of Sheffield, Sheffield, United Kingdom (J.M.W.).

Background Pulmonary function tests are central to diagnosis and monitoring of respiratory diseases but do not provide information on regional lung function heterogeneity. Fluorine 19 (F) MRI of inhaled perfluoropropane permits quantitative and spatially localized assessment of pulmonary ventilation properties without tracer gas hyperpolarization. Purpose To assess regional lung ventilation properties using F MRI of inhaled perfluoropropane in participants with asthma, participants with chronic obstructive pulmonary disease (COPD), and healthy participants, including quantitative evaluation of bronchodilator response in participants with respiratory disease.

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Article Synopsis
  • - Non-invasive evaluation of pulmonary blood flow is crucial for Understanding gas exchange in the lungs, and a chest digital dynamic radiography system (CDDR) can provide visual and quantitative data by capturing changes in lung radiographic transparency in sync with the heartbeat.
  • - The lung-diffusing capacity (DLCO) test assesses factors related to the alveolar membrane and blood flow, and changes in DLCO can indicate variations in pulmonary blood flow, especially in patients with conditions like anaemia or without visible interstitial abnormalities.
  • - The study compared CDDR results with DLCO measurements among patients categorized by their DLCO levels, revealing that the mean and median pulmonary blood flow values obtained through CDDR were significantly lower in those with reduced DLCO,
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Assessing Xe multi-breath washout MRI response to elexacaftor/tezacaftor/ivacaftor intervention in pediatric CF.

J Cyst Fibros

September 2024

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.

Article Synopsis
  • MBW Xe-MRI measures gas washout and ventilation in pediatric cystic fibrosis (CF) patients and its effectiveness in monitoring changes after initiating therapy with elexacaftor/tezacaftor/ivacaftor (ETI) has been evaluated.
  • 12 participants underwent MBW Xe-MRI and pulmonary function tests at baseline and one month after starting ETI therapy, showing significant improvements in ventilation metrics.
  • Findings indicated that MBW Xe-MRI-derived measures like fractional ventilation and coefficient of variation can effectively assess lung function changes, making it a useful tool alongside traditional pulmonary function tests in pediatric CF care.
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Background: The hepatic steatosis and fibrosis related to metabolic dysfunction-associated steatotic liver disease (MASLD) are important factors in the progression. The Multi echo three-dimensional (3D) Dixon sequence can obtain a single breath hold scan for a fat fraction map and an R2* map. The R2* value is usually used to evaluate iron deposition.

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