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Determination of 115 Pesticide Residues in Textiles by Liquid Chromatography-Tandem Mass Spectrometry.
Rapid Commun Mass Spectrom
May 2025
Technology Center of Qingdao Customs, Qingdao, China.
The presence of pesticide residues in textiles poses a risk to human health. We established a robust and high-throughput liquid chromatography-tandem mass spectrometry method for the determination of 115 pesticide residues in textiles. In this study, we evaluated high-performance liquid chromatography-tandem mass spectrometry conditions and sample extraction methods, including separation performance of different columns, mass conditions, extraction solvent, and extraction time.
View Article and Find Full Text PDFPre-folding purification procedures for inclusion body-derived non-tagged cationic recombinant proteins with multiple disulfide bonds for efficient refolding.
Biotechnol Prog
January 2025
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan.
The production of disulfide-containing recombinant proteins often requires refolding of inclusion bodies before purification. A pre-refolding purification step is crucial for effective refolding because impurities in the inclusion bodies interfere with refolding and subsequent purification. This study presents a new pre-refolding procedure using a reversible S-cationization technique for protein solubilization and purification by reversed-phase high performance liquid chromatography.
View Article and Find Full Text PDFDevelopment and validation of a high-performance liquid chromatography method with fluorescence detection for the quantification of the resistance protein P-gp in cancer cells.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Université Clermont Auvergne, Institut Universitaire de Technologie, UMR INSERM-UCA, U1240, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), 5 Avenue Blaise Pascal, 63000 Clermont-Ferrand, France.
A method using high-performance liquid chromatography coupled with fluorescence detection (HPLC-FLD) was developed and validated to quantify the innovative tool LightSpot®-FL-1, a selective permeability-glycoprotein (P-gp)-targeted fluorescent conjugate used to measure P-gp expression in cell samples. Quantifying P-gp is a major challenge in oncology as its overexpression in many cancer cells results in Multidrug Resistance (MDR) associated with chemotherapy failure. To develop the method reported herein, both sample preparation and analysis parameters were investigated.
View Article and Find Full Text PDFSafety and Efficacy of Incorporating Actellic 300 CS into Soil Wall Plaster for Control of Malaria Vectors in Rural Northeastern Uganda.
Trop Med Infect Dis
December 2024
Med Biotech Laboratories, Kampala P.O. Box 9364, Uganda.
Indoor residual spraying (IRS) and the use of insecticide-treated bednets for malaria vector control have contributed substantially to a reduction in malaria disease burden. However, these control tools have important shortcomings including being donor-dependent, expensive, and often failing because of insufficient uptake. We assessed the safety and efficacy of a user-friendly, locally tailored malaria vector control approach dubbed "Hut Decoration for Malaria Control" (HD4MC) based on the incorporation of a WHO-approved insecticide, Actellic 300 CS, into a customary hut decoration practice in rural Uganda where millions of the most vulnerable and malaria-prone populations live in mud-walled huts.
View Article and Find Full Text PDFExploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study.
Curr Drug Metab
January 2025
Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Deverakeggahalli, Kanakapura Road, Ramanagara Distt, Karnataka, 562112, India.
Background: Hypertension, which affects 1.28 billion people globally aged 30 to 79, is characterized by continuously high blood pressure (140/90 or more) and raises the risk of premature death. Losartan, an angiotensin receptor blocker (ARB), is suggested for patients under the age of 55 who cannot take ACE inhibitors as a first treatment option.
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