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Structure and function of a β-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium.
Commun Biol
January 2025
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.
Galactosides are major carbohydrates that are found in plant cell walls and various prebiotic oligosaccharides. Studying the detailed biochemical functions of β-galactosidases in degrading these carbohydrates is important. In particular, identifying β-galactosidases with new substrate specificities could help in the production of potentially beneficial oligosaccharides.
View Article and Find Full Text PDFThe interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity.
J Neuroinflammation
January 2025
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
The thrombolytic protease tissue plasminogen activator (tPA) is expressed in the CNS, where it regulates diverse functions including neuronal plasticity, neuroinflammation, and blood-brain-barrier integrity. However, its role in different brain regions such as the substantia nigra (SN) is largely unexplored. In this study, we characterize tPA expression, activity, and localization in the SN using a combination of retrograde tracing and β-galactosidase tPA reporter mice.
View Article and Find Full Text PDFConservation agricultural practices promoted arbuscular mycorrhizal fungal colonization and glomalin content on sandy clay loam of southern India.
Heliyon
January 2025
ICAR-IIRR, Indian Institute of Rice Research, Hyderabad, 500 030, India.
Arbuscular mycorrhizal Fungi (AMF) are essential in agriculture and are often inter-linked with glomalin-related soil protein (GRSP) production which supports binding of aggregates, enhanced SOC and biological attributes. However, conservation agricultural practices in agroecosystem may have significant impact on AMF diversity, GRSP and soil quality-related parameters (SQRPs). This current experiment was implemented to gauge AMF conization percentage (AMF-CP), GSRP and significant changes on critical SQRPs, and to investigate the linkages between AMF-CP, GRSP and SQRPs as influenced by synergistic tillage and weed management in CA.
View Article and Find Full Text PDFHeterologous Production, Purification and Characterization of Two Cold-Active β-d-Galactosidases with Transglycosylation Activity from the Psychrotolerant Arctic Bacterium sp. S3* Isolated from Spitsbergen Island Soil.
Int J Mol Sci
December 2024
Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland.
Cold-adapted microorganisms possess cold-active enzymes with potential applications in different industries and research areas. In this study, two genes encoding β-d-galactosidases belonging to Glycoside Hydrolase families 2 and 42 from the psychrotolerant Arctic bacterium sp. S3* were cloned, expressed in and , purified and characterized.
View Article and Find Full Text PDFDissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence.
Front Immunol
January 2025
School of Public Health, Suzhou Medicine College of Soochow University, Jiangsu, Suzhou, China.
Introduction: Cancer's inherent heterogeneity, marked by diverse genetic and molecular alterations, presents significant challenges for developing effective treatments. One such alteration is the regulation of disulfidoptosis, a recently discovered programmed cell death pathway. RPN1, a key regulator associated with disulfidoptosis, may influence various aspects of tumor biology, including immune evasion and cellular senescence.
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