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Fumarate hydratase-deficient renal cell carcinoma: a single institution-based study of 29 patients by clinicopathological, immunohistochemical and genetic approaches.
Pathology
February 2025
Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea; Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a renal neoplasm associated with FH loss, aggressive behaviour, and poor survival. We present a histopathological and immunohistochemical overview of FH-deficient RCC to infer significant features for its differential diagnosis. In this study, FH-deficient RCC tissue samples from patients who underwent surgical resection or biopsy at a single institution between July 1995 and August 2022 were reviewed by conventional haematoxylin and eosin staining, immunohistochemistry, and whole genome analyses.
View Article and Find Full Text PDFClinical characteristics and outcomes of invasive pulmonary aspergillosis in renal transplant recipients: A single-center experience.
Transpl Immunol
November 2024
Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address:
Objective: This study aimed to explore the clinical features, early diagnostic methods, and therapeutic approaches for invasive pulmonary aspergillosis (IPA) in patients after renal transplantation (RT).
Methods: We retrospectively examined 22 patients who were diagnosed with IPA post-RT and treated at our institution between 2005 and 2024.
Results: Patients had an average age of 46.
Development and Validation of an Improved HPLC-MS/MS Method for Quantifying Total and Unbound Lenalidomide in Human Plasma.
Pharmaceutics
October 2024
Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
Article Synopsis
- The study developed a validated HPLC-MS/MS method to measure total and unbound lenalidomide levels in human plasma.
- Unbound concentrations were determined using ultrafiltrate from plasma, and extraction involved liquid-liquid methods with specific chromatography techniques.
- The method showed high precision and accuracy in results and was successfully used to analyze lenalidomide levels in multiple myeloma patients with kidney issues.
Epstein-Barr virus-positive plasmacytoma in an immunocompetent female: A case report.
J Clin Exp Hematop
September 2024
Department of Pathology, University of Yamanashi, Chuo, Yamanashi, Japan.
Plasmacytoma is defined as a plasma cell neoplasm forming a solitary osseous or extramedullary tumor without evidence of myeloma or organ damage related to a plasma cell neoplasm. Epstein-Barr virus (EBV) is associated with various B-cell neoplasms, particularly in patients with immune dysregulation; however, plasmacytoma is typically negative for EBV. Here, a case of EBV-positive sternal plasmacytoma in an immunocompetent female is presented.
View Article and Find Full Text PDFSingle-Domain Antibody-Gold Nanoparticle Bioconjugates as Immunosensors for the Detection of Hantaviruses.
Mol Diagn Ther
July 2024
Fundação Oswaldo Cruz, FIOCRUZ, Fiocruz Ceará, Eusébio, CE, Brazil.
Introduction: Hantavirus, a zoonotic pathogen, causes severe syndromes like hemorrhagic fever with renal syndrome (HFRS), sometimes fatal in humans. Considering the importance of detecting the hantavirus antigen, the construction of an immunosensor is essential. The structural and functional characteristics of camelid nanobodies (VHHs) encourage their application in the areas of nanobiotechnology, therapeutics, diagnostics, and basic research.
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