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Membranoproliferative glomerulonephritis (MPGN) has previously been used as an umbrella term to describe a spectrum of hypocomplementemic glomerular diseases, which are rare causes of end stage kidney disease (ESKD). We present a 22-year-old man with a well-established medical history who had been complaining of 4 days of frothy dark urine, bilateral lower limb swelling, and puffiness on his face. For a month before his presentation, he had many bilateral skin lesions on his lower limbs that were leaking pus.
View Article and Find Full Text PDFNew Insights and Future Perspectives of APRIL in IgA Nephropathy.
Int J Mol Sci
September 2024
Department of Nephrology, Juntendo University Urayasu Hospital, Chiba 279-0021, Japan.
Article Synopsis
- IgA nephropathy (IgAN) is an immune-related kidney disease caused by the buildup of a specific type of IgA in the kidney glomeruli, leading to various symptoms and a lack of effective treatments due to incomplete understanding of its mechanisms.
- Recent research identifies the cytokine APRIL as a key player in the production of the problematic IgA1 in IgAN, revealing new potential treatment avenues.
- Initial studies on APRIL-targeting therapies show promise in reducing harmful protein levels in the urine and improving patient outcomes, suggesting potential new treatments for IgAN.
A preliminary probabilistic nomogram model for predicting renal arteriolar damage in IgA nephropathy from clinical parameters.
Front Immunol
July 2024
Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Background: IgA nephropathy (IgAN) is a significant contributor to chronic kidney disease (CKD). Renal arteriolar damage is associated with IgAN prognosis. However, simple tools for predicting arteriolar damage of IgAN remain limited.
View Article and Find Full Text PDFMitochondrial Dysfunction in Systemic Lupus Erythematosus with a Focus on Lupus Nephritis.
Int J Mol Sci
June 2024
Division of Immunology and Allergy, Lausanne University Hospital, CH-1010 Lausanne, Switzerland.
Systemic lupus erythematosus (SLE) is an autoimmune disease affecting mostly women of child-bearing age. Immune dysfunction in SLE results from disrupted apoptosis which lead to an unregulated interferon (IFN) stimulation and the production of autoantibodies, leading to immune complex formation, complement activation, and organ damage. Lupus nephritis (LN) is a common and severe complication of SLE, impacting approximately 30% to 40% of SLE patients.
View Article and Find Full Text PDFIntroduction: IgA nephropathy (IgAN) is a kidney disorder characterized by the deposition of circulating immune complexes of IgG bound to galactose-deficient IgA1 (Gd-IgA1) in the mesangial glomeruli. However, limited research has been conducted on the levels of IgA binding in relation to the various sialylation profiles of IgG in IgAN.
Materials And Methods: Sialylated IgG (SA-IgG) and desialylated IgG (DSA-IgG) were isolated from IgAN patients.
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