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Chronic cannabidiol administration modulates depressive and cognitive alterations induced by social isolation in male mice.
Behav Brain Res
March 2025
Department of Biological Sciences, Laboratory of Neurobiology and Biomaterials (LNBio), Federal University of Ouro Preto, Ouro Preto, Brazil. Electronic address:
Cannabidiol (CBD), a non-psychotropic compound derived from Cannabis sativa, is known for its potential therapeutic effects on central nervous system (CNS) disorders. This study investigates the effects of chronic CBD administration on depressive and cognitive alterations induced by social isolation in male C57BL/6 mice. The experimental design involved adult mice subjected to either group housing or 12 weeks of social isolation.
View Article and Find Full Text PDFDesign and Bottom-up Production of an Aerosolizable Cannabidiol Nanosuspension.
Mol Pharm
January 2025
Department of Pharmaceutical Sciences, (DISFARM), University of Milan, 20133 Milano, Italy.
Cannabidiol (CBD), a small nonpsychoactive molecule derived from , exerts a variety of therapeutic actions, such as anti-inflammatory, antioxidant, and antibacterial. Epidiolex is the only FDA-approved medicine containing pure CBD as an oral solution for seizure-controlling therapy. Nevertheless, the oral bioavailability of CBD is challenging due to its physical-chemical properties such as low solubility in water and high first-pass metabolism.
View Article and Find Full Text PDFEffect of Kruppel-like factor 4 on PTZ-induced acute seizure mice.
J Cell Mol Med
September 2024
Department of Pediatrics, The First Hospital of Jilin University, Changchun, People's Republic of China.
Kruppel-like factor 4 (Klf4) is a transcription factor that is involved in neuronal regeneration and the development of glutamatergic systems. However, it is unknown whether Klf4 is involved in acute seizure. To investigate the potential role of Klf4 in pentylenetetrazol (PTZ)-induced seizure, western blotting, immunofluorescence, behaviour test and electrophysiology were conducted in this study.
View Article and Find Full Text PDFIntroduction: Cyclin-dependent kinase-Like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental condition commonly characterized by drug-resistant, refractory epilepsy, and seizures beginning in infancy. Most patients use multiple drugs, yet seizures remain difficult to control. So far, no conventional anti-seizure medications have been proven to be effective in individuals with CDD, in well-conducted studies.
View Article and Find Full Text PDFEffect of Cannabidiol on Red Blood Cells: Implication in Long-Lasting Pathology Treatment.
Curr Pharm Des
October 2024
Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Universidad de Buenos Aires, Buenos Aires, Argentina.
Background: Cannabidiol (CBD) is the principal non-hallucinogenic compound of Cannabis plants with high clinical interest because CBD has been described as having anti-inflammatory, analgesic and anticonvulsant properties. CBD is considered a multitarget compound as it can interact with a wide range of targets, explaining their multiplicity of effects. Some clinical studies have indicated certain side effects of CBD, including somnolence, anemia and diarrhea, while the elevation of transaminases is considered as an exclusion criterion from the trial.
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