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Overlooked and underpowered: a meta-research addressing sample size in radiomics prediction models for binary outcomes.
Eur Radiol
January 2025
Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objectives: To investigate how studies determine the sample size when developing radiomics prediction models for binary outcomes, and whether the sample size meets the estimates obtained by using established criteria.
Methods: We identified radiomics studies that were published from 01 January 2023 to 31 December 2023 in seven leading peer-reviewed radiological journals. We reviewed the sample size justification methods, and actual sample size used.
External Validation of the Neiman Imaging Comorbidity Index in Medicare, Medicaid, and Private Payer Claims Data.
J Am Coll Radiol
December 2024
Director of Economic and Health Services Research, The Harvey L. Neiman Health Policy Institute, Reston, Virginia.
Objective: The Neiman Imaging Comorbidity Index (NICI) was developed and validated in a claims dataset encompassing >10 million privately insured beneficiaries, in which it outperformed the commonly used Charlson Comorbidity Index (CCI) in predicting advanced imaging use. This external validation assessed the broader generalizability of NICI for predicting receipt of advanced imaging in nationally representative populations, including patients insured by Medicare, Medicaid, and private payers.
Methods: All 2018 to 2019 patient-level claims from the CMS Medicare 5% Research Identifiable File, CMS Medicaid 100% Research Identifiable File, and private insurance (commercial and Medicare Advantage) claims from Inovalon Insights, LLC, were included.
3-Dimensional (3D) Isotropic MRI of the Shoulder - Advantages Over 2D MRI.
Semin Roentgenol
October 2024
Department of Radiology, UT Southwestern, University of Dallas, Richardson, TX; Adjunct faculty - Johns Hopkins University, Baltimore, MD; Walton Center of Neurosciences, Liverpool, UK. Electronic address:
The increasing implementation of high-field MRI scanners and the development of novel imaging techniques have rendered 3D imaging of joints more feasible and efficient than ever. This article describes the current state of 3D MRI of the shoulder and highlights the benefits of the technique over conventional 2D MRI with respect to shoulder derangements.
View Article and Find Full Text PDFEvolving Trainee Participation in Radiologists' Workload Using A National Medicare-Focused Analysis From 2008 to 2020.
J Am Coll Radiol
January 2025
Section Head, Abdominal Imaging, and Director of Health Policy, Department of Radiology, NYU Grossman School of Medicine, New York, New York; American College of Radiology Board of Chancellors (Chair, Commission on Body Imaging); and Editor-in-Chief, American Journal of Roentgenology.
Purpose: Increasing volumes and productivity expectations, along with practice type consolidation, may be impacting trainees' roles in the work effort of radiologists involved in education. We assessed temporal shifts in trainee participation in radiologists' workload nationally.
Methods: All US radiologists interpreting noninvasive diagnostic imaging for Medicare fee-for-service beneficiaries were identified from annual 5% Research Identifiable Files from 2008 to 2020 (n = 35,595).
Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells.
Nat Commun
June 2024
Research Institute for Systems Biology and Medicine, Moscow, 117246, Russian Federation.
Ovarian cancer often develops resistance to conventional therapies, hampering their effectiveness. Here, using ex vivo paired ovarian cancer ascites obtained before and after chemotherapy and in vitro therapy-induced secretomes, we show that molecules secreted by ovarian cancer cells upon therapy promote cisplatin resistance and enhance DNA damage repair in recipient cancer cells. Even a short-term incubation of chemonaive ovarian cancer cells with therapy-induced secretomes induces changes resembling those that are observed in chemoresistant patient-derived tumor cells after long-term therapy.
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