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Corydalis hendersonii Hemsl. protects against myocardial injury by attenuating inflammation and fibrosis via NF-κB and JAK2-STAT3 signaling pathways.
J Ethnopharmacol
July 2017
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, PR China. Electronic address:
Ethnopharmacological Relevance: Corydalis hendersonii Hemsl. (CH) with heat clearing and detoxifying effects are well described in Tibetan folk medicine. It has been used for centuries in China largely for the treatment of high altitude polycythemia, a pathophysiological condition referred to "plethora" in Tibetan medicine, hypertension, hepatitis, edema, gastritis, and other infectious diseases.
View Article and Find Full Text PDFThe angiotensin-converting enzyme inhibitor captopril rescues mice from endotoxin-induced lethal hepatitis.
Innate Immun
February 2017
4 Department of Pathogenic Biology, Chongqing Medical University, Chongqing, China.
The renin-angiotensin system is classically regarded as a crucial regulator of circulatory homeostasis, but recent studies also revealed its pro-inflammatory roles. The beneficial effects of the angiotensin-converting enzyme inhibitor (ACEI) in severe inflammatory injury in the lung and heart have been previously reported, but its potential effects on lethal hepatitis were unknown. In this study, a mouse model with LPS/d-galactosamine (GalN)-induced fulminant hepatitis were used to test the protective potential of captopril, a representative ACEI.
View Article and Find Full Text PDFRamipril-induced liver injury: case report and review of the literature.
Am J Hypertens
September 2013
Department of Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Article Synopsis
- Ramipril, an ACE inhibitor commonly used for hypertension, has been linked to rare instances of liver injury, with this study presenting the first confirmed case of ramipril-induced hepatotoxicity.
- The patient, a 40-year-old male, experienced severe liver enzyme elevation after taking ramipril, with improvements noted after stopping the drug and worsened liver function upon re-exposure.
- The study emphasizes the importance of monitoring and awareness among healthcare professionals regarding the potential liver-related side effects of ramipril, despite the overall rarity of ACEI-induced hepatotoxicity.
Side effects of the therapy with peginterferon and ribavirin in chronic hepatitis C: a small audit.
J Pharm Pract
February 2012
Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil.
This study sought to decribe, quantify, and classify any adverse reactions occurring in patients with chronic hepatitis C treated with peginterferon and ribavirin, as well as verify the occurrence of potential medication interactions. The most prevalent reactions were fatigue (84.8%), fever (83%), weight loss (80%), irritability (74%), and body pain (72%).
View Article and Find Full Text PDFDrug hypersensitivity syndrome.
Indian J Dermatol Venereol Leprol
June 2011
Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry-605 006, India.
Drug hypersensitivity syndrome (DHS) is an adverse drug reaction commonly associated with the aromatic antiepileptic drugs (AEDs), viz., phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), lamotrigine, primidone, etc. It can also be caused by other drugs, such as sulfonamides, dapsone, minocycline, gold derivatives, cyclosporine, captopril, diltiazem, terbinafine, azathioprine and allopurinol.
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