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Fiery Connections: Macrophage-Mediated Inflammation, the Journey from Obesity to Type 2 Diabetes Mellitus and Diabetic Kidney Disease.
Biomedicines
September 2024
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Article Synopsis
- The rising rates of diabetes mellitus, especially type 2 diabetes (T2D), present major public health issues, particularly due to diabetic kidney disease (DKD) being a severe consequence.
- Research highlights how macrophages, a type of inflammatory cell, play a crucial role in the onset and progression of DKD linked to obesity-related T2D.
- By targeting macrophage activation, new therapies could potentially help manage DKD at various stages of its progression, showing promise for improving patient outcomes.
Monocytes/macrophages are pivotal in host defense, inflammation, and tissue repair. They are actively engaged during helminth infections, playing critical roles in trapping pathogens, eliminating them, repairing tissue damage, and mitigating type 2 inflammation. These cells are indispensable in preserving physiological equilibrium and overseeing pathogen resistance as well as metabolic processes.
View Article and Find Full Text PDFMetabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancers.
J Immunother Cancer
September 2024
Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences, La Tronche, France
Background: Tumor-associated macrophages participate in the complex network of support that favors tumor growth. Among the various strategies that have been developed to target these cells, the blockade of the colony-stimulating factor 1 receptor (CSF-1R) receptor is one of the most promising ones. Here, we characterize the resulting state of human macrophages exposed to a CSF-1R kinase inhibitor.
View Article and Find Full Text PDFAngelica sinensis polysaccharides ameliorate 5-FU-induced stress anemia via promoting extramedullary erythroblastic island central macrophage-mediated erythroid differentiation.
Int Immunopharmacol
December 2024
Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing 400016, China. Electronic address:
Article Synopsis
- Chronic anemia, especially from chemotherapy, is a serious problem that can be hard to treat and can cause side effects from traditional treatment options.
- Researchers studied how a substance from a Chinese herb called Angelica sinensis (ASP) helps mice recover from anemia caused by the chemotherapy drug 5-fluorouracil (5-FU).
- The study found that ASP helped mice produce more red blood cells and other blood components by improving their bone marrow and spleen function, showing that it could be a helpful treatment for anemia caused by cancer treatments.
A novel molecular classification based on efferocytosis-related genes for predicting clinical outcome and treatment response in acute myeloid leukemia.
Inflamm Res
November 2024
Jiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Background: Previous studies have shown that macrophage-mediated efferocytosis is involved in immunosuppression in acute myeloid leukemia (AML). However, the regulatory role of efferocytosis in AML remains unclear and needs further elucidation.
Methods: We first identified the key efferocytosis-related genes (ERGs) based on the expression matrix.
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