The cultivation of V. cholerae was carried out in casein broth in a fermenter. 2 kinds of cultivation conditions were compared. The results thus obtained indicate that the cultivation of V. cholerae under the conditions of the controlled level of dissolved oxygen (pO2--50%) ensures the optimum conditions for proliferation and the high yield of biomass; it also allows obtaining vaccine whose immunogenic properties are not inferior to those of the WHO reference vaccine.
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