When a woman with chronic renal disease wishes to become pregnant, the risk to the mother and the foetus is often inaccurately evaluated or exaggerated. In patients with primary nephropathy the foetal risk is significantly increased by the arterial hypertension frequently associated with renal insufficiency. In systemic lupus erythematosus (SLE) with renal involvement, the risk represented by hypertension is compounded by a high incidence of spontaneous abortion, particularly when the disease is progressive. Pregnancy seems to have little influence on SLE itself, and the classical post-partum problems are controversial. Much more dangerous are acute complications, such as cortical necrosis or haemolytic and uraemic syndromes occurring in apparently healthy women during the last trimester of pregnancy and after delivery. Urinary infections are common during pregnancy. They are heralded by asymptomatic bacteriuria which should be systematically detected, since these infections increase the likelihood of pyelonephritis with in turn increases the severity of perinatal complications.
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Hemodial Int
January 2025
DaVita Patient Safety Organization, Denver, Colorado, USA.
Introduction: Chronic kidney disease-mineral and bone disorder (CKD-MBD), is a common syndrome in end stage kidney disease (ESKD) patients, is marked by dysregulation of electrolytes and hormones, including calcium, phosphorus and parathyroid hormone (PTH). Calcimemetics are a cornerstone of PTH lowering therapy; cinacalcet, an oral calcimemetic, is the most used and typically prescribed as a daily administration, thus contributing to the high total pill burden of this population. Recent clinical trials have provided evidence that administration of cinacalcet at the dialysis unit three times a week might be a safe and effective treatment option.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
January 2025
Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, District of Columbia, USA.
Patients with type 2 diabetes mellitus (DM) are more susceptible to microvascular complications. However, whether DM is associated with coronary microvascular dysfunction (CMD) is unclear. This observational study used data from the Coronary Microvascular Disease Registry (CMDR) (NCT05960474) and included patients with angina and no obstructive coronary artery disease (ANOCA) who underwent invasive CMD evaluation using the CoroVentis CoroFlow System (Abbott Vascular, Santa Clara, CA).
View Article and Find Full Text PDFAims: Large-scale, real-world data on early initiation of sacubitril/valsartan in patients newly diagnosed (de novo) with HF with reduced ejection fraction (HFrEF) are limited. We examined the effectiveness of sacubitril/valsartan versus angiotensin-converting enzyme inhibitor (ACEi)/angiotensin receptor blocker (ARB) on all-cause and cause-specific hospitalizations among patients with de novo HFrEF from the Optum® dataset in the United States.
Methods: This retrospective cohort study included adult patients with de novo HFrEF (diagnosed ≤30 days) with left ventricular ejection fraction (LVEF) ≤40% who were first prescribed with sacubitril/valsartan or ACEi/ARB from 1 January 2016 to 31 March 2020.
J Biochem Mol Toxicol
February 2025
Calcium Signaling Laboratory, Veterans Affairs Medical Center, Research Service, Washington, District of Columbia, USA.
Crystalline nephropathy (CN) is characterized by deposition of microcrystals within the kidney tubular microstructure, specifically in the renal tubular cells. Nephropathic conditions have been observed in kidney stone patients as nephrocalcinosis, resulting from the deposition of calcium phosphate (CaP) microcrystals mainly within the renal tubule. CaP microcrystals trigger nephrotoxicity and cell death leading to acute and chronic kidney disease and in some cases end stage renal disease.
View Article and Find Full Text PDFJ Craniofac Surg
January 2025
Department of Otorhinolaryngology-Head & Neck Surgery, Daegu Fatima Hospital, Daegu, Republic of Korea.
Angiomyolipoma (AML), composed of smooth muscle cells, blood vessels, and adipose tissues, belongs to a family of tumors originating from perivascular epithelioid cells. Angiomyolipoma most commonly arises in the kidney but is extremely rare in the nasal cavity. Angiomyolipoma is classified into hepatorenal and mucocutaneous AML.
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