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Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy.

Front Bioeng Biotechnol

January 2025

Department of Neurosurgery, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Shenyang, China.

Cancer is a major killer threatening modern human health and a leading cause of death worldwide. Due to the heterogeneity and complexity of cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number of researchers and medical professionals are working to develop new ways to treat cancer.

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Currently in wheat breeding, genome wide association studies (GWAS) have successfully revealed the genetic basis of complex traits such as nitrogen use efficiency (NUE) and its biological processes. In the GWAS model, thresholding is common strategy to indicate deviation of expected range of -(s), and it can be used to find the distribution of true positive associations under or over of test statistics. Therefore, the threshold plays a critical role to identify reliable and significant associations in wide genome, while the proportion of false positive results is relatively low.

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Editorial: Studying child development in a changing world.

J Child Psychol Psychiatry

February 2025

Wolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, UK.

In this editorial, I reflect on the implications of social, technological and cultural change for children and young people. Whilst we have a reasonably good understanding of trends in certain aspects of child development (e.g.

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QTL mapping and candidate gene analysis of element accumulation in rice grains via genome-wide association study and population genetic analysis.

BMC Plant Biol

January 2025

Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, China.

Background: Toxic heavy metal elements in soils are major global environmental issues and easily migrate to crop grains to cause severe problems in human health, whereas moderately essential elements such as selenium are beneficial for human health. The accumulation of heavy metals and essential elements in rice grains and their genetic mechanisms are still poorly understood.

Results: We conducted genetic dissection of four toxic heavy metal elements (lead, cadmium, mercury, and chromium), one quasi metallic element (arsenic), and one essential element (selenium) in grains of 290 Xian and 308 Geng rice accessions through a genome-wide association study (GWAS) based on three statistical models and assays of element concentrations from three environments.

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Globalizing opposition to pro-environmental institutions: The growth of counter climate change organizations around the world, 1990 to 2018.

PLoS One

January 2025

Graduate School of Education and Doerr School of Sustainability, Stanford University, Stanford, California, United States of America.

More than two decades of social scientific research has identified the growing network of corporations, think tanks, nonprofits, and advocacy organizations that aim to obstruct climate change action within the United States. Conventional arguments emphasize the role of economic self-interest (e.g.

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