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Blood levels of cytokines highlight the role of inflammation in Alzheimer's disease.
Heliyon
January 2025
Laboratory of Brain Aging and Neurodegeneration, Fundación Instituto Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, Ciudad Autónoma de Buenos Aires, Argentina.
Inflammation and angiogenesis have been defined as potential mechanisms associated with clinical progression from a cognitively normal state to Alzheimer's disease (AD). In this observational case-control study, we aimed to determine plasma levels of cytokines as indicators of inflammation involved in cognitive decline. We measured 30 plasma proteins in 49 controls (CTL), 36 individuals with mild cognitive impairment (MCI) and 52 patients diagnosed with probable AD.
View Article and Find Full Text PDFAcute respiratory tract infections during the first six years of life - results from the German birth cohort study LoewenKIDS.
Int J Infect Dis
January 2025
Institute of Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle Saale, Germany; Helmholtz Centre for Infection Research, Epidemiology Research Group Epidemiological and Statistical Methods, 38124 Braunschweig, Germany. Electronic address:
Objectives: Acute respiratory infections (ARI) often occur in early childhood and are mostly self-limited. However, they impose a high socioeconomic burden and can be associated with chronic diseases later in life. To date, data on self-reported ARI beyond infancy are limited.
View Article and Find Full Text PDFEvaluation of three fixation methods in tibiotalocalcaneal fusion for chronic osteomyelitis following ankle fracture.
J Clin Orthop Trauma
February 2025
Instituto de Ortopedia y Trauma Dr. Jaime Slullitel, San LUIS 2534 2000, Rosario, Santa Fe, Argentina.
Introduction: In the scenario of chronic osteomyelitis following an ankle fracture, limb salvage and ideally infection eradication, can be an alternative to amputation.Tibiotalocalcaneal arthrodesis is perhaps the most popular procedure. When performing fusion in osteomyelitis patients, external fixation is more commonly used, although there is some experience with internal fixation.
View Article and Find Full Text PDFCharting the epitranscriptomic landscape across RNA biotypes using native RNA nanopore sequencing.
Mol Cell
January 2025
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain; Universitat Pompeu Fabra, Barcelona 08003, Spain; ICREA, Pg. Lluís Companys 23, Barcelona 08010, Spain. Electronic address:
RNA modifications are conserved chemical features found in all domains of life and across diverse RNA biotypes, shaping gene expression profiles and enabling rapid responses to environmental changes. Their broad chemical diversity and dynamic nature pose significant challenges for studying them comprehensively. These limitations can now be addressed through direct RNA nanopore sequencing (DRS), which allows simultaneous identification of diverse RNA modification types at single-molecule and single-nucleotide resolution.
View Article and Find Full Text PDFProblematic gambling among the LGBTQIA2S + population in Canada: A quantitative study.
Addict Behav
January 2025
Department of Family Medicine and Emergency Medicine, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada; Centre de recherche du Centre hospitalier universitaire de Sherbrooke, 12e Avenue N Porte 6, Sherbrooke, Quebec J1H 5N4, Canada. Electronic address:
Background And Aims: LGBTQIA2S + populations are believed to be at higher risk of problem gambling due to their elevated rates of mental disorders and substance abuse compared to heterosexual and cisgender populations. However, little is known about these populations regarding their gambling practices in the Canadian context.
Methods: We conducted an online survey among Canadian residents 18 years or older who self-identify as sexually and gender-diverse (i.
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