Ten patients with myotonic dystrophy were allocated at random to treatment with disopyramide and procainamide in a cross-over trial. Disopyramide was found to be at least as effective as procainamide in the relief of myotonia; and two patients who could not tolerate procainamide both tolerated disopyramide.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083128PMC
http://dx.doi.org/10.1136/jnnp.45.5.461DOI Listing

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