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Clusterin mediates hydroquinone-induced cytotoxic responses in HL-60 differentiated cells.
Sci Rep
December 2024
Medical Laboratory, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, 518020, China.
Benzene is a crucial industrial hydrocarbon, posing significant health risks due to its toxic metabolites like hydroquinone (HQ). This study investigates the role of clusterin (CLU) in benzene toxicity by analyzing its protein and mRNA levels, as well as the expression of Bcl-2 and Bax, to evaluate the feasibility of CLU as a biomarker for chronic benzene poisoning. HL-60 cells were induced to differentiate into neutrophil-like cells using 1% Dimethyl Sulfoxide (DMSO).
View Article and Find Full Text PDFNavigating diagnostic dilemmas: a rare presentation of extramedullary T-lymphoblastic leukemia/lymphoma with chronic myeloid leukemia.
J Hematop
December 2024
Department of Pathology, Microbiology, and Immunology University of Nebraska Medical Center, Omaha, NE, USA.
Chronic myeloid leukemia (CML) typically presents in the chronic phase. The blast crisis phase in CML predominantly comprises the myeloid phenotype, while B-cell lymphoblastic crisis is common among the lymphoid lineages. Presentation as a T-lymphoblastic crisis is exceptionally rare.
View Article and Find Full Text PDFAssociation between ABO blood groups and hematological myeloid neoplasms in adolescents and adults.
Front Med (Lausanne)
September 2024
Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Background: Prior research suggests a potential link between ABO blood types and susceptibility to various malignancies. The correlation between ABO blood types and hematological myeloid neoplasms, however, remains inadequately explored.
Objective: This study investigates the association between ABO blood groups and the incidence of hematological myeloid neoplasms in adolescents and adults.
Ultrastructure Microscopic Characterization of Apoptosis in Myelomoncytic Leukemia Cell Line Treated with Velogenic Viscerotropic Newcastle Disease Virus Strain AF 2240.
Asian Pac J Cancer Prev
September 2024
Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Selangor, Malaysia.
Article Synopsis
- Leukemia is a type of cancer that affects the bone marrow and is categorized as either acute or chronic, depending on how quickly it spreads, and as myelocytic or lymphocytic based on the type of white blood cells involved.
- The study investigated the effects of the Newcastle Disease Virus (NDV) strain AF2240 on WEHI 3B leukemia cells using advanced microscopy techniques to observe cell changes and apoptosis (programmed cell death).
- Results showed that NDV caused significant changes in cell structure and decreased cell viability, with signs of early apoptosis detected within six hours of treatment, indicating potential for NDV in developing new leukemia therapies.
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J Pharmacol Exp Ther
August 2024
Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Japan.
Article Synopsis
- - The study explores the roles of nitric oxide (NO) from the nitric oxide synthases system (NOSs) in inter-organ communication and its implications for health disorders.
- - Research using mice lacking all three NOS types showed that deficiencies in NO led to severe health issues, such as sudden heart attacks and worsened vascular conditions, highlighting NO's protective role between the kidneys, heart, and blood vessels.
- - The findings suggest that targeting systemic and bone marrow-derived NOSs could be beneficial in developing treatments for conditions like myocardial infarction, vascular disease, and pulmonary hypertension.
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