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The Somogyi hypothesis: a parallelism with Michael Somogyi's life.
Hormones (Athens)
December 2024
Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Oviedo, Spain.
Michael Somogyi (Somogyi Mihály, 1883-1971) was a Hungarian biochemist who developed his scientific career in Europe and, primarily, the United States. He gave the name to the eponymous Somogyi effect or Somogyi hypothesis (in short, rebound hyperglycemia after insulin-induced hypoglycemia, particularly nocturnal), which was an axiom in the treatment of diabetes for decades. Although it is currently debated whether the Somogyi hypothesis is a real or relevant phenomenon in patients with diabetes, Somogyi's other significant career achievements are often overlooked.
View Article and Find Full Text PDFMeasuring the impact: Severity of harm from laboratory errors in 195 tests.
Am J Clin Pathol
October 2024
Department of Medical Biochemistry, Acibadem Mehmet Ali Aydinlar University, Ankara, Turkiye.
Article Synopsis
- * Results indicated that certain tests, particularly cardiac biomarkers, blood gases, and specific drug levels, were perceived to pose a higher risk for patient harm due to erroneous results.
- * There was strong agreement (91%) between medical biochemists and clinicians regarding the severity scores, highlighting the tests that require focused quality improvement efforts.
Maud L. Menten: Pioneering Physician and Biochemist.
Cureus
August 2024
Internal Medicine, Wellstar Health System, Marietta, USA.
Article Synopsis
- Dr. Maud Leanora Menten was a pioneering Canadian physician and biochemist who made significant contributions to various fields of biochemistry for over 40 years, particularly in cancer treatments and enzyme kinetics.
- She was a trailblazer for women in science, being among the first in Canada to earn both an MD and a PhD, and after facing restrictions, she published around 100 research studies, notably collaborating with Dr. Leonor Michaelis on the famous Michaelis-Menten equation.
- Although her contributions in hemoglobin research were overshadowed by Linus Pauling, her legacy gained recognition posthumously, with honors from the University of Toronto and the Canadian Medical Hall of Fame.
Comparison of Various Low Density Lipoprotein Cholesterol Calculators: Is It Time for the Friedewald Equation to Go in India?
J Assoc Physicians India
September 2024
Consultant Biochemist, Dr Mehta's Multispecialty Hospital, Chennai, Tamil Nadu, India.
Background And Objectives: Low-density lipoprotein cholesterol (LDL-c) is the main target in the management of dyslipidemia in primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD). Our study aims to compare the conventional and most popular Friedewald equation, and the more recent Sampson equation (literally unknown in India but more accurate), to the directly estimated LDL-c by the homogenous method. No such comparative study has been done in India.
View Article and Find Full Text PDFLife and Times of Yellapragada SubbaRow.
J Assoc Physicians India
August 2024
Consultant Rheumatologist, Department of Rheumatology, Centre for Rheumatology, Kozhikode, Kerala; Department of Medicine, Kasturba Medical College, MAHE, Manipal, Karnataka, India, OrcidID: https://orcid.org/0000-0002-5035-7396.
Dr Yellapragada SubbaRow was an Indian-born American biochemist who made numerous discoveries in various fields of science. Born in 1895 into a poor family, he went on to have medical training at the Madras Medical College, Chennai, Tamil Nadu, India. After many hardships, he arrived in the United States of America and earned a diploma in tropical medicine and a PhD in biochemistry from Harvard.
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