The cellular localization of the brain-specific, soluble, acidic alpha 2-glycoprotein was studied in rat cerebellum by using the immunoperoxidase technique at the light-and electron-microscopy levels with monospecific immune serum directed against this glycoprotein. Only astrocytes, their processes, and their end feet (subpial or perivascular) contained heavy immunoperoxidase reaction product. Cerebellar neurones, oligodendrocytes, myelin and blood vessel endothelia did not stain. Thus it appears that alpha 2-glycoprotein is an astrocyte marker.
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