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Characterization of serotype 6 strains from geographically diverse low- and middle-income countries.
mBio
January 2025
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Article Synopsis
- Serotype 6 is a common cause of moderate to severe diarrhea but remains understudied, prompting research into its genomic and phenotypic characteristics compared to other serotypes.
- Genomic analyses revealed notable similarities among 6 strains across different regions and timeframes, along with the identification of a potential novel virulence factor and unique patterns of antibiotic susceptibility specific to geographic locations.
- Findings suggest that serotype 6 has distinct genetic and phenotypic traits that could enhance vaccine development and diagnostic tools, which is crucial given the rising incidence of shigellosis, particularly in low- and middle-income countries.
"Molecular Characterization of Extended Spectrum Beta-Lactamase Resistance in Pediatric Shigella Isolates in Egypt".
Biochem Genet
November 2024
Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Shigellosis is a major cause of morbidity and mortality among children, especially in developing countries. The increased extended-spectrum beta-lactamase (ESBL) resistance in Shigella poses a challenge for effective treatment. To examine the antibiotic resistance and ESBL profile of Shigella isolates from children with acute diarrhea.
View Article and Find Full Text PDFAn outbreak of acute diarrhoeal disease caused by Shigella sonnei in a village in Dibrugarh district, Assam.
Indian J Med Res
July 2024
Integrated Disease Surveillance Programme, Dibrugarh, Assam, India.
Article Synopsis
- Food and waterborne illnesses are a major public health concern in India, often linked to large gatherings and poor food handling practices, as seen in an acute diarrheal disease outbreak at a birthday party in rural Assam.
- The investigation involved collecting demographic data, illness details, rectal swabs, and water samples, revealing that 25 people were affected, with Shigella sonnei identified as the pathogen responsible for the outbreak.
- The study highlighted a significant association between illness and the consumption of chicken curry, indicating a high attack rate and resistance of the pathogen to several antibiotics, while the water quality was deemed safe.
Shigella and Enterotoxigenic Escherichia coli Have Replaced Rotavirus as Main Causes of Childhood Diarrhea in Rwanda After 10 Years of Rotavirus Vaccination.
J Infect Dis
November 2024
Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Sweden.
The causes of diarrhea after 10 years of rotavirus vaccination in Rwanda were investigated with real-time polymerase chain reaction in 496 children with diarrhea and 298 without. Rotavirus was detected in 11% of children with diarrhea (odds ratio, 2.48; P = .
View Article and Find Full Text PDFRisk Factors of Seizure in Childhood Shigellosis.
Iran J Child Neurol
March 2024
Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Objectives: Shigellosis is one of the common causes of bacterial diarrhea in children. Seizures are common in shigellosis. It is essential to identify the risk factors of seizure in this disease.
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