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New onset work disability in rheumatoid arthritis is an underrecognized cardiovascular risk factor: A retrospective cohort study using the CorEvitas registry.
Semin Arthritis Rheum
February 2025
Hospital for Special Surgery, Division of Rheumatology, New York, NY, USA; Weill Cornell Medicine, Division of General Internal Medicine, New York, NY, United States of America. Electronic address:
Article Synopsis
- - Patients younger than 65 with rheumatoid arthritis (RA) who experience new-onset work disability face a significantly higher risk of cardiovascular disease (CVD) compared to their working counterparts.
- - The study found that the incidence rate of CVD was 5.40 per 1,000 person-years in those with work disability versus 2.17 in the working group, with an adjusted hazard ratio indicating a more than double risk for those with work disability.
- - Despite analyzing various factors such as functional status and traditional CVD risks, the study concluded that the increased CVD risk in newly disabled patients remains partly unexplained, suggesting that other factors like social determinants of health may play a role.
Optimizing the Preoperative Preparation of Sarcopenic Older People: The Role of Prehabilitation and Nutritional Supplementation before Knee Arthroplasty.
Nutrients
October 2024
Geriatric Clinic Unit, University Hospital of Parma, Via Gramsci 14, 43126 Parma, Italy.
Article Synopsis
- Age-related loss of muscle strength and mass, known as sarcopenia, can negatively impact postoperative recovery in older patients, especially those with severe osteoarthritis who need knee surgery.
- This study reviews existing literature on the effectiveness of prehabilitation and dietary supplementation in improving outcomes for older sarcopenic patients before knee arthroplasty, focusing on interventions that enhance physical function and surgical resilience.
- Combining exercise training with nutrient supplementation may lead to better functional capacity and reduced surgical complications, highlighting the importance of addressing both sarcopenia and osteoarthritis in this demographic.
Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL).
PLoS Med
August 2024
Université Paris Cité, Faculté de Santé, UFR de Médecine, Paris, France.
Article Synopsis
- * The trial involved 142 participants, who were randomly assigned to receive either 40 mg of resveratrol twice daily or a placebo for 6 months, measuring changes in knee pain on a scale of 0 to 100.
- * Results showed similar reductions in knee pain for both groups after 3 months, with a mean decrease of -15.7 in the resveratrol group and -15.2 in the placebo group, indicating no significant difference in effectiveness.
Cervical and Ocular Vestibular Evoked Myogenic Potentials in Fibromyalgia Syndrome Patients.
J Int Adv Otol
May 2024
Department of Otolaryngology, Audio-Vestibular Unit, Cairo University, Kasr-Al-Ainy Faculty of Medicine, Cairo, Egypt.
Background: Fibromyalgia syndrome (FMS) is a chronic pain condition that may be associated with dysfunction in the central nervous system.
Objective: The aim of this study was to assess the vestibulo-spinal reflex (VSR) and vestibulo-ocular reflex (VOR) in FMS using the cervical vestibular evoked myogenic potential (cVEMP) and ocular vestibular evoked myogenic potential (oVEMP) tests, respectively, and to evaluate their relation to disease severity.
Methods: This study included 30 female FMS patients and 30 well-matched healthy controls.
Hip and knee replacement in lower limb amputees: a scoping review.
BMC Musculoskelet Disord
March 2024
University of Exeter, St Lukes Campus, Magdalen Road, Exeter, Devon, EX1 2LU, UK.
Background: There are many consequences of lower limb amputation, including altered biomechanics of gait. It has previously been shown that these can lead to increased rates of osteoarthritis (OA). A common and successful treatment for severe OA is joint replacement.
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